Aluminum-Induced Cognitive Impairment and PI3K/Akt/mTOR Signaling Pathway Involvement in Occupational Aluminum Workers

N Shang, P Zhang, S Wang, J Chen, R Fan… - Neurotoxicity …, 2020 - Springer
Epidemiological studies indicate that long-term occupational exposure to aluminum (Al)
causes neurotoxicity and cognitive impairment. While the molecular underpinnings …

Aluminum-induced synaptic plasticity impairment via PI3K-Akt-mTOR signaling pathway

H Li, X Xue, L Li, Y Li, Y Wang, T Huang, Y Wang… - Neurotoxicity …, 2020 - Springer
Aluminum (Al) is an environmental neurotoxin with extensive exposure by humans, but the
molecular mechanism of its toxicity is still unclear. Several studies have indicated that …

The relationship between plasma Al levels and multi-domain cognitive performance among in-service aluminum-exposed workers at the SH aluminum factory in …

S Wang, H Meng, N Shang, J Guo, T Zhang, S Zhang… - Neurotoxicology, 2020 - Elsevier
Abstract Background Aluminum (Al) exerts neurotoxic effects following overexposure. We
previously reported worse cognitive performance in workers exposed to Al than non …

Aluminum exposure and cognitive performance: A meta-analysis

T Vlasak, T Dujlovic, A Barth - Science of the Total Environment, 2024 - Elsevier
Background Aluminum is increasingly used in various industrial processes due to its
beneficial properties. Occupational exposure to aluminum, however, has been linked to …

[HTML][HTML] Increased aluminum and lithium and decreased zinc levels in plasma is related to cognitive impairment in workers at an aluminum factory in China: a cross …

N Shang, L Zhang, S Wang, T Huang, Y Wang… - Ecotoxicology and …, 2021 - Elsevier
Background Previous studies have shown that multiple imbalances of metal ions in the brain
are closely associated with the neurodegenerative disorders. Our studies have shown that …

Post-exposure self-recovery reverses oxidative stress, ameliorates pathology and neurotransmitters imbalance and rescues spatial memory after time-dependent …

H Asghar, A Siddiqui, L Batool, Z Batool, T Ahmed - BioMetals, 2024 - Springer
Aluminum is a potent neurotoxin, responsible for memory impairment and cognitive
dysfunction. The neurotoxic effect of aluminum on cognitive impairment is well documented …

Cross-sectional study based on occupational aluminium exposure population

S Xu, Y Zhang, X Ju, D Gao, H Yang, L Wang… - Environmental …, 2021 - Elsevier
To evaluate the different characteristics of cognitive impairment caused by occupational
aluminium exposure at different ages, we surveyed 1660 workers in Shanxi Aluminium …

[HTML][HTML] Lnc001209 Participates in aluminium-induced apoptosis of PC12 cells by regulating PI3K-AKT-mTOR signalling pathway

H Li, Q Zhang, X Xue, J Zhang, S Wang, J Zhang… - Ecotoxicology and …, 2023 - Elsevier
Aluminium (Al) is a common environmental neurotoxin, but the molecular mechanism
underlying its toxic effects remains unclear. Many studies have shown that aluminium …

Longitudinal study of the effects of occupational aluminium exposure on workers' cognition

X Lu, S Xu, Y Zhang, D Gao, H Yang, J Song, L Wang… - Chemosphere, 2021 - Elsevier
Objective To explore the effects of occupational aluminium (Al) exposure on workers'
cognition through a longitudinal study. Methods The study population consisted of 276 …

Transcriptome-wide identification of differentially expressed genes and long non-coding RNAs in aluminum-treated rat hippocampus

Y Xu, H Zhang, B Pan, S Zhang, S Wang, Q Niu - Neurotoxicity Research, 2018 - Springer
Aluminum (Al) is an environmental neurotoxicant with a wide exposure, but the molecular
mechanism underlying its toxicity remains unclear. We used RNA sequencing (RNA-seq) in …