Structural evidence for the evolution of pyrogenic toxin superantigens
DT Mitchell, DG Levitt, PM Schlievert… - Journal of molecular …, 2000 - Springer
Pathogenic bacteria have evolved a wide variety of toxins to invade and attack host
organisms. In particular, strains of the bacteria Staphylococcus aureus and Streptococcus …
organisms. In particular, strains of the bacteria Staphylococcus aureus and Streptococcus …
[HTML][HTML] Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and …
The protein toxins known as superantigens (SAgs), which are expressed primarily by the
pathogenic bacteria Staphylococcus aureus and Streptococcus pyogenes, are highly potent …
pathogenic bacteria Staphylococcus aureus and Streptococcus pyogenes, are highly potent …
Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1)
MD Baker, I Gendlina, CM Collins… - Protein science, 2004 - Wiley Online Library
Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen associated with
scarlet fever and streptococcal toxic shock syndrome (STSS). SpeA1 is found in both …
scarlet fever and streptococcal toxic shock syndrome (STSS). SpeA1 is found in both …
Molecular structure of staphylococcus and streptococcus superantigens
PM Schlievert, GA Bohach, DH Ohlendorf… - Journal of clinical …, 1995 - Springer
Staphylococcus aureus and streptococci, notably those belonging to group A, make up a
large family of true exotoxins referred to as pyrogenic toxin superantigens. These toxins …
large family of true exotoxins referred to as pyrogenic toxin superantigens. These toxins …
The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 Å resolution
AC Papageorgiou, RD Brehm, DD Leonidas… - Journal of molecular …, 1996 - Elsevier
The pyrogenic toxin toxic shock syndrome toxin-1 fromStaphylococcus aureusis a causative
agent of the toxic shock syndrome disease. It belongs to a family of proteins known as …
agent of the toxic shock syndrome disease. It belongs to a family of proteins known as …
Expression, purification, and detection of novel streptococcal superantigens
JK McCormick, PM Schlievert - Superantigen Protocols, 2003 - Springer
Superantigens (SAgs) are a class of bacterial or viral proteins that aberrantly alter immune
system function through simultaneous interaction with lateral surfaces of major …
system function through simultaneous interaction with lateral surfaces of major …
[HTML][HTML] Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T‐cell receptors
AC Papageorgiou, CM Collins, DM Gutman… - The EMBO …, 1999 - embopress.org
Streptococcal pyrogenic exotoxin A (SpeA) is a superantigen produced by Streptococcus
pyogenes and is associated with severe infections characterized by rash, hypotension …
pyogenes and is associated with severe infections characterized by rash, hypotension …
Structural features of a zinc binding site in the superantigen strepococcal pyrogenic exotoxin A (SpeA1): implications for MHC class II recognition
M Baker, DM Gutman, AC Papageorgiou… - Protein …, 2001 - Wiley Online Library
Streptococcal pyrogenic exotoxin A (SpeA) is produced by Streptococcus pyogenes, and
has been associated with severe infections such as scarlet fever and Streptococcal Toxic …
has been associated with severe infections such as scarlet fever and Streptococcal Toxic …
Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes
Recently, we described the identification of novel streptococcal superantigens (SAgs) by
mining the Streptococcus pyogenes M1 genome database at Oklahoma University. Here, we …
mining the Streptococcus pyogenes M1 genome database at Oklahoma University. Here, we …
The role of superantigens in human diseases
PM Schlievert - Current Opinion in Infectious Diseases, 1995 - journals.lww.com
Many of the infections caused by group A streptococci and Staphylococcus aureus depend
upon these organisms' ability to produce exotoxins. Pyrogenic toxin superantigens, a large …
upon these organisms' ability to produce exotoxins. Pyrogenic toxin superantigens, a large …