Genetics of Lipoprotein (a)

G Utermann - Lipoprotein (a), 2023 - Springer
Abstract Lipoprotein (a)(Lp (a)) is a macromolecular complex consisting of LDL and the
characteristic apolipoprotein (a)(apo (a)). Lp (a) occurs as a quantitative genetic trait with …

Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp (a) in plasma

V Mooser, FP Mancini, S Bopp… - Human molecular …, 1995 - academic.oup.com
Most of the Interindividual variations in plasma levels of lipoprotein (a)[Lp (a)] can be
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

Molecular genetics of lipoprotein (a): new pieces to the puzzle

A Gaw, HH Hobbs - Current opinion in lipidology, 1994 - journals.lww.com
Important advances have been made in the past year in our understanding of the genetics of
lipoprotein (a)[Lp (a)]. The apolipoprotein (a)[APO (a)] gene has been cloned and mice have …

Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.

CA DeMeester, X Bu, RJ Gray, AJ Lusis… - American journal of …, 1995 - ncbi.nlm.nih.gov
Abstract Lipoprotein (a)(Lp [a]) is a cholesterol-rich lipoprotein resembling LDL but also
containing a large polypeptide designated apolipoprotein (a)(apo [a]). Its levels are highly …

Molecular definition of the extreme size polymorphism in apolipoprotein (a)

C Lackner, JC Cohen, HH Hobbs - Human molecular genetics, 1993 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)], an atherogenic lipoprotein, consists of an LDL particle
complexed with a large glycoprotein, apollpoprotein (a)[apo (a)]. Apo (a) is one of the most …

Genetics of plasma lipoprotein (a) concentrations

E Boerwinkle - Current Opinion in Lipidology, 1992 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is a low-density-like lipoprotein with the addition of a Lp (a)-
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …

Lipoprotein (a) in homozygous familial hypercholesterolemia

HG Kraft, A Lingenhel, FJ Raal… - … , and vascular biology, 2000 - Am Heart Assoc
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait that in the general population is largely
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …

[引用][C] Genetic architecture of the atherogenic lipoprotein (a)

G Utermann, C Haibach, M Trommsdorff… - Annals of the New …, 1994 - Wiley Online Library
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait in human plasma that is almost
unaffected by age, diet, or life-style. Thc distribution of Lp (a) plasma concentrations is …