Metabolic effects of increased mechanical work were studied by comparing isolated
pumping rat hearts perfused by the atrial-filling technique with aortic-perfused non-pumping …

The aim of this work was to establish the reasons why ketone bodies, although readily
oxidized, do not sustain a physiological work output of the isolated rat heart for more than 30 …

1. The ability of tricarboxylic acid-cycle metabolites to influence the physiological
performance of the perfused anaerobic rat heart was investigated. Energy expenditure/h …

1. An improved perfusion system for the isolated rat heart is described. It is based on the
isolated working heart of Neely, Liebermeister, Battersby & Morgan (1967)(Am. J. Physiol …

Summary and Conclusions 1. Oxidation rates employing a-ketoglutarate as substrate and
efficiency of phosphorylation coupled with oxidation were studied in heart mitochondrial …

Addition of insulin or a physiological ratio of ketone bodies to buffer with 10 mM glucose
increased efficiency (hydraulic work/energy from O2 consumed) of working rat heart by 25 …

Previous studies have indicated that ketone body-mediated contractile failure in rat hearts is
due to inhibition of 2-oxoglutarate dehydrogenase, and it has been speculated that this …

Results In the experiments summarized graphically in Fig. 1, a comparison has been made
of the oxygen uptakes resulting when nB-hydroxybutyrate, L-@-hydroxybutyrate, and …

Energy liberated from substrates of heart muscle metabolism appears as mechanical work
and heat. External mechanical work and heat production of the left ventricle were compared …

Knowledge of the redox state of the free NAD'/NADH couple in the mitochondria is essential
in assessing the state of mitochondrial terminal oxidations. This is particularly important …