Production of monomeric IgA in mammalian cells and plant expression systems such as
Nicotiana benthamiana is well-established and can be achieved by co-expression of the …

The production of therapeutic antibodies to combat pathogens and treat diseases, such as
cancer is of great interest for the biotechnology industry. The recent development of plant …

IgA nephropathy (IgAN) is a common autoimmune disease that is characterized by formation
and deposition of IgA1-containing immune complexes frequently leading to end-stage …

Proper N-and O-glycosylation of recombinant proteins is important for their biological
function. Although the N-glycan processing pathway of different expression hosts has been …

N‐glycosylation is critical for recombinant glycoprotein production as it influences the
heterogeneity of products and affects their biological function. In most eukaryotes, the …

The full potential of recombinant Immunoglobulin A as therapeutic antibody is not fully
explored, owing to the fact that structure–function relationships of these extensively …

N-Glycosylation of immunoglobulin G1 (IgG1) at the heavy chain Fc domain (Asn297) plays
an important role for antibody structure and effector functions. While numerous recombinant …

As biopharmaceuticals, recombinant proteins have become indispensable tools in medicine.
An increasing demand, not only in quantity but also in diversity, drives the constant …

N‐glycosylation is one of the major post‐translational modifications of proteins in
eukaryotes; however, the processing reactions of oligomannosidic N‐glycan precursors …

Glycoengineering is increasingly being recognized as a powerful tool to generate
recombinant glycoproteins with a customized N-glycosylation pattern. Here, we demonstrate …