Islet transplantation offers improved glycemic control in individuals with type 1 diabetes
mellitus. However, in vitro islet culture is associated with islet apoptosis and eventually will …

The maintenance of viable and functional islets is critical in successful pancreatic islet
transplantation from cadaveric sources. During the isolation procedure, islets are exposed to …

Islet transplantation may be the most efficient therapeutic technique for patients with type 1
diabetes mellitus (T1DM). However, the clinical application of this method is faced with …

Ectogenic pancreatic islet transplantation has long been discussed as having the potential
to reverse diabetes. The aim of the present study was to evaluate the therapeutic efficacy of …

Background aims Adipose tissue–derived mesenchymal stromal cells (AT-MSCs), widely
known as multipotent progenitors, release several cytokines that support cell survival and …

Background. There is no clear consensus on the effect of coculture of islets with
mesenchymal stem cells (MSCs) on islet function and viability. Methods. We conducted a …

Islet transplantation is an emerging treatment for type 1 diabetes which offers the prospect of
physiological control of blood glucose and reductions in acute hypoglycaemic episodes …

Background Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction
of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was …

The clinical usability of pancreatic islet transplantation for the treatment of type I diabetes,
despite some encouraging results, is currently hampered by the short lifespan of the …

Transplantation of human islets is an attractive alternative to daily insulin injections for
patients with type 1 diabetes. However, the majority of islet recipients lose graft function …