Crosstalk of a tumor with its microenvironment is a critical factor contributing to cancer
development. This study investigates the soluble factors released by tumor-associated …

Accumulating evidence suggests that tumor-infiltrating immune cells (TICs) in the tumor
microenvironment (TME) serve as promising therapeutic targets. CXCL8 (IL-8) may also be …

Abstract Background Activation of CXCL12/CXCR4 axis has been found to be associated
with invasion and metastasis in many cancers. However, the underlying mechanism remains …

Cancer stem cells (CSCs) are considered to be the origin of cancer relapse and metastasis.
The better understanding of CSCs, including CSCs in human colorectal cancer (CRC), may …

Tumor micro‐environment is a critical factor in the development of cancer. The aim of this
study was to investigate the inflammatory cytokines secreted by tumor‐associated dendritic …

Chemokines (CXCR3) and their ligands (CXCL9, CXCL10, and CXCL11) exert exquisite
control over T-cell trafficking and are critical for activation, differentiation and effector T cell …

Background Metastasis is a major cause of death in human colorectal cancer patients.
However, the contribution of chemokines in the tumor microenvironment to tumor metastasis …

Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular
development and enable evasion of anti-tumour immune responses, by disabling infiltrating …

Mesenchymal stem cells (MSCs) extensively interact with cancer cells and other stroma cells
in the tumor microenvironment. However, the role of MSCs in colorectal cancer (CRC) …

Despite many advances and optimization in colon cancer treatment, tumor recurrence and
metastases make the development of new therapies necessary. Colon cancer stem cells …