Multifunctional magnetic nanoclusters can induce immunogenic cell death and suppress tumor recurrence and metastasis

L Zhang, Q Zhang, DT Hinojosa, K Jiang, QK Pham… - ACS …, 2022 - ACS Publications
Metastasis is the predominant cause of cancer deaths due to solid organ malignancies;
however, anticancer drugs are not effective in treating metastatic cancer. Here we report a …

A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity

Z Yang, X Guo, M Meng, T Li, H Fang, Z Tang, H Tian… - Nano Research, 2023 - Springer
As a revolutionary cancer treatment strategy, immunotherapy has attracted great attention.
However, the effect of immunotherapy such as immune checkpoint blockade (ICB) is usually …

Vitamin k3-loaded magnetic nanoparticle-mediated synergistic magnetothermodynamic therapy evokes massive ROS and immune modulation for augmented …

A Chauhan, K Anjaly, A Saini, R Kumar… - … applied materials & …, 2023 - ACS Publications
Magnetic nanoparticle (MNP)-mediated magnetic hyperthermia (MHT) under an alternating
magnetic field (AMF) causes tumor regression via reactive oxygen species (ROS) …

Biocompatible nanoclusters with high heating efficiency for systemically delivered magnetic hyperthermia

HA Albarqi, LH Wong, C Schumann, FY Sabei… - ACS …, 2019 - ACS Publications
Despite its promising therapeutic potential, nanoparticle-mediated magnetic hyperthermia is
currently limited to the treatment of localized and relatively accessible cancer tumors …

Combined magnetic hyperthermia and immune therapy for primary and metastatic tumor treatments

J Pan, P Hu, Y Guo, J Hao, D Ni, Y Xu, Q Bao, H Yao… - ACS …, 2020 - ACS Publications
Cancer immunotherapy shows promising potential in future cancer treatment but
unfortunately is clinically unsatisfactory due to the low therapeutic efficacy and the possible …

Nanoassembly with self-regulated magnetic thermal therapy and controlled immuno-modulating agent release for improved immune response

M Gao, K Feng, X Zhang, Y Ruan, G Zhao, H Liu… - Journal of Controlled …, 2023 - Elsevier
Cancer immunotherapy is an emerging cancer therapeutic method by activating the patient's
immune system but suffers from low immunogenicity at tumor sites. Fever-like heat is known …

Enhancement of CD8+ T‐Cell‐Mediated Tumor Immunotherapy via Magnetic Hyperthermia

Y Zhang, X Gao, B Yan, N Wen, WSV Lee… - …, 2022 - Wiley Online Library
Magnetic hyperthermia (MHT) uses magnetic iron oxide nanoparticles (MIONs) to irradiate
heat when subjected to an alternating magnetic field (AMF), which then trigger a series of …

[HTML][HTML] Magnetic nanostructures as emerging therapeutic tools to boost anti-tumour immunity

S Persano, P Das, T Pellegrino - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapy represents an attractive therapeutic option for effective
treatment of different forms of cancers. However, many patients exhibit primary or acquired …

Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer

H Gavilán, SK Avugadda… - Chemical Society …, 2021 - pubs.rsc.org
Magnetic hyperthermia (MHT) is a therapeutic modality for the treatment of solid tumors that
has now accumulated more than 30 years of experience. In the ongoing MHT clinical trials …

Heat-generating iron oxide multigranule nanoclusters for enhancing hyperthermic efficacy in tumor treatment

S Jeon, BC Park, S Lim, HY Yoon… - … applied materials & …, 2020 - ACS Publications
The development of heat-generating magnetic nanostructures is critical for the effective
management of tumors using magnetic hyperthermia. Herein, we demonstrate that …