How I treat unique and difficult-to-manage cases of CAR T-cell therapy–associated neurotoxicity

BD Santomasso, J Gust, F Perna - Blood, The Journal of the …, 2023 - ashpublications.org
With growing indications for chimeric antigen receptor (CAR) T-cell therapy, toxicity profiles
are evolving. There is an urgent and unmet need of approaches to optimally manage …

How I treat refractory CRS and ICANS after CAR T-cell therapy

MD Jain, M Smith, NN Shah - … Journal of the American Society of …, 2023 - ashpublications.org
The clinical use of chimeric antigen receptor (CAR) T-cell therapy is growing rapidly
because of the expanding indications for standard-of-care treatment and the development of …

Neurological updates: neurological complications of CAR-T therapy

EC Tallantyre, NA Evans, J Parry-Jones… - Journal of …, 2021 - Springer
Chimeric antigen receptor (CAR)-expressing T cells now offer an effective treatment option
for people with previously refractory B cell malignancies and are under development for a …

Immune effector cell associated neurotoxicity syndrome in chimeric antigen receptor-T cell therapy

RC Sterner, RM Sterner - Frontiers in immunology, 2022 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy is an emerging staple in the treatment of
certain hematological malignancies. While CAR-T cells have produced robust responses in …

Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies

C Yang, J Nguyen, Y Yen - Journal of Biomedical Science, 2023 - Springer
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat
relapsed or refractory hematological malignancies. However, the adverse effects of CAR-T …

In the eye of the storm: immune-mediated toxicities associated with CAR-T cell therapy

JG Borrega, P Gödel, MA Rüger, ÖA Onur… - …, 2019 - journals.lww.com
The success of chimeric antigen receptor (CAR)-T cell therapy with impressive response
rates in hematologic malignancies but also promising data in solid tumors came along with …

Clinical presentation, risk factors, and outcomes of immune effector cell-associated neurotoxicity syndrome following chimeric antigen receptor T cell therapy: a …

SJ Grant, AA Grimshaw, J Silberstein… - … and cellular therapy, 2022 - Elsevier
Chimeric antigen receptor (CAR) T cell therapy is a novel therapy for patients with relapsed
or refractory hematologic malignancies. Most CAR T cell therapy recipients will experience …

Neurotoxicity—CAR T-cell therapy: what the neurologist needs to know

L Neill, J Rees, C Roddie - Practical Neurology, 2020 - pn.bmj.com
Chimeric antigen receptor (CAR) T-cell therapy is one of the most innovative therapies for
haematological malignancies to emerge in a generation. Clinical studies have shown that a …

Neurological adverse effects of chimeric antigen receptor T-cell therapy

K Saleki, MH Mohamadi, P Alijanizadeh… - Expert Review of …, 2023 - Taylor & Francis
Introduction Chimeric antigen receptor (CAR) T-cell is among the most prevalent
approaches that act by directing T-cells toward cancer; however, they need to be optimized …

CAR T-cell-associated neurotoxicity in central nervous system hematologic disease: Is it still a concern?

R Velasco, A Mussetti, M Villagrán-García… - Frontiers in …, 2023 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell systemic immunotherapy has revolutionized how
clinicians treat several refractory and relapsed hematologic malignancies. Due to its peculiar …