It was suggested that bacterial products can inhibit the expression of leucocyte chemokine
receptors during sepsis and affect leucocyte functions in septic syndrome. Superantigens …

Literature reveals that interaction with live Staphylococcus aureus (S. aureus) or heat killed
S. aureus (HKSA) promotes secretion of CXCL-8 or interleukin-8 (IL-8) from leukocytes …

Currently, very few studies are available on the expression of CXCR1 in mouse
macrophages having both intact TNFR1 and IL-1R or their deficiency in relation to acute S …

TNF-α is implicated in the initiation of cytokine cascades in various inflammatory settings. To
assess the interactions of multiple cytokines at the level of inflammatory effector cells, we …

Interaction with the live Staphylococcus aureus promotes secretion of interleukin-8 (IL-8),
although the expressions of functional CXCR1 (IL-8RA) in murine macrophages have not …

Neutrophil migration to the site of bacterial infection is a critical step in host defense.
Exclusively produced in the bone marrow, neutrophil release into the blood is tightly …

Rationale: The failure of neutrophils to migrate to an infection focus during severe sepsis is
an important determinant of the inability of a host to deal with an infectious insult. Our …

Several lines of evidence have suggested that a CXC chemokine receptor 4
(CXCR4)/stromal cell-derived factor-1 [SDF-1; CXC chemokine ligand 12 (CXCL12)] pair is …

In Edinburgh, we have been interested in delineating early specific inflammatory events
associated with ARDS disease progression. We have previously reported that an elevated …

CXC chemokines play a central role in regulation of neutrophil activation and chemotaxis.
Because the chemotactic responses of neutrophils are impaired after phagocytosis, we …