Abstract To determine whether 1, 25‐dihydroxyvitamin D (1, 25 (OH) 2D) can exert an anti‐
osteoporosis role through anti‐aging mechanisms, we analyzed the bone phenotype of mice …

Recent studies suggest that vitamin D signaling regulates bone formation. However, the
overall effect of 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] on bone turnover in vivo is still …

We tested the hypothesis that 1, 25‐dihydroxyvitamin D3 [1α, 25 (OH) 2D3] has antiaging
effects via upregulating nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2), reducing reactive …

1, 25-Dihydroxyvitamin D [1, 25 (OH) 2D] insufficiency appears to be associated with several
age-related diseases. Insufficient levels of serum 25-hydroxyvitamin D has been shown to …

1, 25-dihydroxyvitamin D3 (1, 25D3) was reported to induce premature organismal aging in
fibroblast growth factor-23 (Fgf23) and klotho deficient mice, which is of main interest as 1 …

Previous studies have shown that 1, 25 (OH) 2 D plays an anti-osteoporosis role by an anti-
aging mechanism. Oxidative stress is a key mediator of aging and bone loss; however …

Hydroxyvitamin D3 [25 (OH) D3] has recently been found to be an active hormone. Its
biological actions are demonstrated in various cell types. 25 (OH) D3 deficiency results in …

The most biologically active metabolite 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) has well
known direct effects on osteoblast growth and differentiation in vitro. The precursor 25 …

Vitamin D plays a major role in the regulation of mineral homeostasis and affects bone
metabolism. So far, detailed knowledge on the vitamin D endocrine system in human bone …

Osteoporosis is a highly prevalent public health burden associated with an increased risk of
bone fracture, particularly in aging women. Estrogen, an important medicinal component for …