A growing number of epigenome-wide association studies have demonstrated a role for
DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral …

Introduction Alzheimer's disease is a neurodegenerative disorder that is hypothesized to
involve epigenetic dysregulation of gene expression in the brain. Methods We performed an …

Background Alzheimer's disease affects~ 13% of people in the United States 65 years and
older, making it the most common neurodegenerative disorder. Recent work has identified …

To better understand DNA methylation in Alzheimer's disease (AD) from both mechanistic
and biomarker perspectives, we performed an epigenome-wide meta-analysis of blood DNA …

Abstract Background Late-onset Alzheimer's disease (AD) is a complex multifactorial
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …

Epigenome-wide association studies of Alzheimer's disease have highlighted
neuropathology-associated DNA methylation differences, although existing studies have …

Background Alzheimer's disease is a progressive neurodegenerative disorder that is
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …

Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder
that likely involves epigenetic factors. To better understand the epigenetic state associated …

Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …

Alzheimer's disease is a neurodegenerative disorder clinically defined by gradual cognitive
impairment and alteration in executive function. We conducted an epigenome-wide …