[HTML][HTML] Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

A Stukalov, V Girault, V Grass, O Karayel, V Bergant… - Nature, 2021 - nature.com
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …

Proteomic approaches to study SARS-CoV-2 biology and COVID-19 pathology

P Haas, M Muralidharan, NJ Krogan… - Journal of proteome …, 2021 - ACS Publications
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative
agent of coronavirus disease 2019 (COVID-19), was declared a pandemic infection in March …

[HTML][HTML] Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

D Bojkova, K Klann, B Koch, M Widera, D Krause… - Nature, 2020 - nature.com
A new coronavirus was recently discovered and named severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). Infection with SARS-CoV-2 in humans causes coronavirus …

Ubiquitin-modified proteome of SARS-CoV-2-infected host cells reveals insights into virus–host interaction and pathogenesis

H Zhang, H Zheng, J Zhu, Q Dong, J Wang… - Journal of Proteome …, 2021 - ACS Publications
The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to global …

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

J Li, M Guo, X Tian, C Liu, X Wang, X Yang, P Wu… - BioRxiv, 2020 - biorxiv.org
The ongoing coronavirus disease (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a global public health concern due …

Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis

Z Chen, C Wang, X Feng, L Nie, M Tang… - The EMBO …, 2021 - embopress.org
Host–virus protein–protein interactions play key roles in the life cycle of severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2). We conducted a comprehensive …

[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

[HTML][HTML] A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Y Zhou, Y Liu, S Gupta, MI Paramo, Y Hou, C Mao… - Nature …, 2023 - nature.com
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus nonstructural proteins identifies unique and shared host-cell dependencies

JP Davies, KM Almasy, EF McDonald… - ACS infectious …, 2020 - ACS Publications
Human coronaviruses (hCoVs) have become a threat to global health and society, as
evident from the SARS outbreak in 2002 caused by SARS-CoV-1 and the most recent …

[HTML][HTML] Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

HH Hoffmann, FJ Sánchez-Rivera, WM Schneider… - Cell host & …, 2021 - cell.com
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
devastated the global economy and claimed more than 1.7 million lives, presenting an …