Investigating TSPO levels in occupation-related posttraumatic stress disorder

SE Watling, T Gill, EV Gaudette, JD Richardson… - Scientific reports, 2023 - nature.com
Microglia are immune brain cells implicated in stress-related mental illnesses including
posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on …

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

S Bhatt, AT Hillmer, MJ Girgenti, A Rusowicz… - Nature …, 2020 - nature.com
Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD),
there are no studies of brain immunologic regulation in individuals with PTSD.[11C] PBR28 …

The association of psychosocial risk factors for mental health with a brain marker altered by inflammation: A translocator protein (TSPO) PET imaging study

T Dahoun, MA Calcia, M Veronese, P Bloomfield… - Brain, Behavior, and …, 2019 - Elsevier
Psychiatric disorders associated with psychosocial risk factors, including depression and
psychosis, have been shown to demonstrate increased microglia activity. Whilst preclinical …

Personality traits in psychosis and psychosis risk linked to TSPO expression: A neuroimmune marker

C Gerritsen, Y Iyengar, T DaSilva, A Koppel… - Personality …, 2020 - cambridge.org
Personality has been correlated with differences in cytokine expression, an indicator of
peripheral inflammation; however, the associations between personality and central markers …

[HTML][HTML] Neuroinflammation in World Trade Center responders at midlife: a pilot study using [18F]-FEPPA PET imaging

Y Deri, SAP Clouston, C DeLorenzo… - Brain, Behavior, & …, 2021 - Elsevier
Background Neuroinflammation has long been theorized to arise from exposures to fine
particulate matter and to be modulated when individuals experience chronic stress, both of …

TSPO expression and brain structure in the psychosis spectrum

S Hafizi, E Guma, A Koppel, T Da Silva, M Kiang… - Brain, behavior, and …, 2018 - Elsevier
Psychosis is associated with abnormal structural changes in the brain including decreased
regional brain volumes and abnormal brain morphology. However, the underlying causes of …

Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice

S Li, Y Liao, Y Dong, X Li, J Li, Y Cheng… - Journal of …, 2021 - Springer
Background Alteration of immune status in the central nervous system (CNS) has been
implicated in the development of post-traumatic stress disorder (PTSD). However, the nature …

Post-traumatic stress disorder: focus on neuroinflammation

J Li, L Tong, BC Schock, LL Ji - Molecular Neurobiology, 2023 - Springer
Post-traumatic stress disorder (PTSD), gaining increasing attention, is a multifaceted
psychiatric disorder that occurs following a stressful or traumatic event or series of events …

Imaging of astrocytes in posttraumatic stress disorder: A PET study with the monoamine oxidase B radioligand [11C] SL25. 1188

T Gill, SE Watling, JD Richardson, T McCluskey… - European …, 2022 - Elsevier
Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that results
from exposure to traumatic event (s). Decreased astrocyte-related proteins (eg, glial fibrillary …

Microglia Loss and Astrocyte Activation Cause Dynamic Changes in Hippocampal [18F]DPA-714 Uptake in Mouse Models of Depression

J Guo, T Qiu, L Wang, L Shi, M Ai, Z Xia… - Frontiers in cellular …, 2022 - frontiersin.org
Major depression is a serious and chronic mental illness. However, its etiology is poorly
understood. Although glial cells have been increasingly implicated in the pathogenesis of …