Objectives: The objective of this systematic review and meta-analysis was to assess acute
kidney injury with combination therapy of vancomycin plus piperacillin-tazobactam, in …

Critically ill patients are frequently treated with empirical antibiotic therapy, including
vancomycin and β-lactams. Recent evidence suggests an increased risk of acute kidney …

Study Objective To evaluate the association of the development of acute kidney injury (AKI)
when piperacillin‐tazobactam is used in combination with vancomycin compared with …

Concomitant vancomycin and piperacillin/tazobactam (PT) may be associated with
increased acute kidney injury (AKI) compared to vancomycin without PT. Medline …

Study Objective The combination of vancomycin and piperacillin‐tazobactam has been
associated with an increased risk of acute kidney injury (AKI) in non–critically ill patient …

Study Objective To evaluate the observed incidence of acute kidney injury (AKI) in adult
patients receiving either piperacillin‐tazobactam and vancomycin or cefepime‐vancomycin …

Background Acute kidney injury is a major complication of vancomycin treatment, especially
when it is co-administered with other nephrotoxins. Objectives This meta-analysis aims to …

Background. Recent evidence suggests that among patients receiving vancomycin, receipt
of concomitant piperacillin–tazobactam increases the risk of nephrotoxicity. Well-controlled …

Background: Patients often receive broad-spectrum antibiotics for nosocomial infections
commonly with activity against Pseudomonas aeruginosa and methicillin-resistant …

BACKGROUND Empiric antimicrobial therapy often consists of the combination of gram‐
positive coverage with vancomycin (VAN) and gram‐negative coverage, specifically an …