Novel thermosensitive hydrogel promotes spinal cord repair by regulating mitochondrial function

Y Li, L Yang, F Hu, J Xu, J Ye, S Liu… - … Applied Materials & …, 2022 - ACS Publications
The repair of spinal cord injury (SCI) is still a tough clinical challenge and needs innovative
therapies. Mitochondrial function is significantly compromised after SCI and has emerged as …

A chitosan-based thermosensitive scaffold loaded with bone marrow-derived mesenchymal stem cells promotes motor function recovery in spinal cord injured mice

J Zhang, T Cheng, Y Chen, F Gao, F Guan… - Biomedical …, 2020 - iopscience.iop.org
Spinal cord injury is a devastating trauma with high mortality and disability, for which there is
no effective treatment. Stem cell-based tissue engineering has been reported to promote …

An electroconductive hydrogel scaffold with injectability and biodegradability to manipulate neural stem cells for enhancing spinal cord injury repair

H Liu, Y Feng, S Che, L Guan, X Yang, Y Zhao… - …, 2022 - ACS Publications
Spinal cord injury (SCI) generally leads to long-term functional deficits and is difficult to
repair spontaneously. Many biological scaffold materials and stem cell treatment strategies …

Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in …

M Yao, J Li, J Zhang, S Ma, L Wang, F Gao… - Journal of Materials …, 2021 - pubs.rsc.org
Recently, an advanced stem cell and tissue engineering approach has been recognized as
an emerging and fascinating strategy to promote neural repair in spinal cord injury (SCI) …

[HTML][HTML] An injectable heparin-Laponite hydrogel bridge FGF4 for spinal cord injury by stabilizing microtubule and improving mitochondrial function

C Wang, Z Gong, X Huang, J Wang, K Xia, L Ying… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Spinal cord injury (SCI) remains a critical clinical challenge. The controlled
release of FGF4, a novel neuroprotective factor, from a versatile Laponite hydrogel to the …

A thermosensitive heparin-poloxamer hydrogel bridges aFGF to treat spinal cord injury

Q Wang, Y He, Y Zhao, H Xie, Q Lin, Z He… - … Applied Materials & …, 2017 - ACS Publications
Acidic fibroblast growth factor (aFGF) exerts a protective effect on spinal cord injury (SCI) but
is limited by the lack of physicochemical stability and the ability to cross the blood spinal …

A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury via synergism …

W He, X Zhang, X Li, D Ju, T Mao, Y Lu, Y Gu… - Journal of Materials …, 2022 - pubs.rsc.org
Spinal cord injury (SCI), as a serious disabling disease, is still haunted by lacking of effective
treatments. We previously found that transplantation of menstrual blood-derived …

Restoration of spinal cord biophysical microenvironment for enhancing tissue repair by injury-responsive smart hydrogel

C Fan, W Yang, L Zhang, H Cai, Y Zhuang, Y Chen… - Biomaterials, 2022 - Elsevier
Spinal cord injury (SCI) represents a central nervous system disaster, resulting in the
destruction of spinal cord structure and function and the formation of an adverse …

Multimodal therapy strategy based on a bioactive hydrogel for repair of spinal cord injury

EJ Roh, DS Kim, JH Kim, CS Lim, H Choi, SY Kwon… - Biomaterials, 2023 - Elsevier
Traumatic spinal cord injury results in permanent and serious neurological impairment, but
there is no effective treatment yet. Tissue engineering approaches offer great potential for …

[HTML][HTML] A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

B Yang, C Liang, D Chen, F Cheng, Y Zhang, S Wang… - Bioactive materials, 2022 - Elsevier
The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the
biological microenvironment by filling the injured cavity area and increasing neuronal …