Docetaxel is recommended as a second-line chemotherapy agent for the non-small-cell
lung cancer (NSCLC); however, drug resistance greatly limits its efficiency. Forkhead box …

The Forkhead box M1 transcription factor (FoxM1) is essential for DNA replication and
mitosis, and has important role in cell proliferation and apoptosis. To assess the role of …

BACKGROUND: The transcription factor Forkhead box M1 (FoxM1) is known to play an
important role in the development and progression of many malignancies including lung …

The underlying molecular mechanisms of cisplatin resistance in non‑small cell lung cancer
(NSCLC) are unclear. In this study, a novel differential methylation region located in the …

Purpose Platinum-based drugs, particularly cisplatin (DDP), are used in the treatment of non-
small cell lung cancer (NSCLC). However, development of drug resistance remains the …

Aim: Gefitinib is effective in only approximately 20% of patients with non-small-cell lung
cancer (NSCLC), and the underlying mechanism remains unclear. FoxM1 is upregulated in …

Resistance to chemotherapy is a main obstacle for effective treatment of gastric cancer, the
mechanism of which is still poorly understood. Forkhead box M1 (FoxM1) plays an important …

Low sensitivity to chemotherapy has been a major challenge in the treatment of non-small-
cell lung cancer (NSCLC). It is of great clinical significance to discover its mechanisms to …

Gefitinib resistance remains a major problem in the treatment of lung adenocarcinoma.
However, the molecular mechanisms of gefitinib resistance are not fully understood. In this …

Carboplatin is the most commonly used drug in the first-line treatment of human
retinoblastoma (RB), but its clinical application is greatly limited due to acquired drug …