Unraveling the complex genetics of neural tube defects: From biological models to human genomics and back
Neural tube defects (NTDs) are a classic example of preventable birth defects for which
there is a proven‐effective intervention, folic acid (FA); however, further methods of …
there is a proven‐effective intervention, folic acid (FA); however, further methods of …
Closing in on mechanisms of open neural tube defects
S Lee, JG Gleeson - Trends in neurosciences, 2020 - cell.com
Neural tube defects (NTDs) represent a failure of the neural plate to complete the
developmental transition to a neural tube. NTDs are the most common birth anomaly of the …
developmental transition to a neural tube. NTDs are the most common birth anomaly of the …
Micronutrient imbalance and common phenotypes in neural tube defects
AD Kakebeen, L Niswander - genesis, 2021 - Wiley Online Library
Neural tube defects (NTDs) are among the most common birth defects, with a prevalence of
close to 19 per 10,000 births worldwide. The etiology of NTDs is complex involving the …
close to 19 per 10,000 births worldwide. The etiology of NTDs is complex involving the …
Gene–environment interactions underlying the etiology of neural tube defects
CD Caiaffa, CSR Fonteles, L Yunping… - Current Topics in …, 2023 - Elsevier
Neural tube defects (NTDs) consist of severe structural malformations of the brain and spinal
cord and are the second most common structural birth defect in humans, accounting for …
cord and are the second most common structural birth defect in humans, accounting for …
Folate‐mediated one‐carbon metabolism and neural tube defects: Balancing genome synthesis and gene expression
AE Beaudin, PJ Stover - Birth Defects Research Part C: Embryo …, 2007 - Wiley Online Library
Neural tube defects (NTDs) refer to a cluster of neurodevelopmental conditions associated
with failure of neural tube closure during embryonic development. Worldwide prevalence of …
with failure of neural tube closure during embryonic development. Worldwide prevalence of …
Human neural tube defects: genetic causes and prevention
Neural tube defects (NTDs) are severe congenital malformations affecting 1–2 in 1,000 live
births, whose etiology is multifactorial, involving environmental and genetic factors. NTDs …
births, whose etiology is multifactorial, involving environmental and genetic factors. NTDs …
The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects
In this paper, we trace the history of current research into the genetic and biochemical
mechanisms that underlie folate‐preventable neural tube defects (NTDs). The inspired …
mechanisms that underlie folate‐preventable neural tube defects (NTDs). The inspired …
Investigations into the etiology of neural tube defects
RM Cabrera, DS Hill, AJ Etheredge… - Birth Defects Research …, 2004 - Wiley Online Library
Neural tube defects (NTDs) are serious malformations affecting approximately 1 per 1000
births, yet the mechanisms by which they arise are unknown. There have been consistent …
births, yet the mechanisms by which they arise are unknown. There have been consistent …
Genetic risk factors for folate-responsive neural tube defects
Neural tube defects (NTDs) are the most severe congenital malformations of the central
nervous system. The etiology is complex, with both genetic and environmental factors …
nervous system. The etiology is complex, with both genetic and environmental factors …
The role of folate transport and metabolism in neural tube defect risk
RC Barber, EJ Lammer, GM Shaw, KA Greer… - Molecular genetics and …, 1999 - Elsevier
Neural tube defects (NTDs) are common congenital malformations in humans. While
etiologically heterogeneous, for the most part they are multifactorial in their pathogenesis …
etiologically heterogeneous, for the most part they are multifactorial in their pathogenesis …
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- genetic causes tube defects
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- micronutrient imbalance tube defects
- carbon metabolism tube defects
- signaling pathways tube defects
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- gene expression tube defects
- genome synthesis tube defects