The effects of intracoronary infusions of substance P in conscious humans on epicardial
vessel diameter and coronary sinus oxygen saturation were investigated in 13 patients who …

BACKGROUND The effects of the endothelium-dependent vasodilator substance P (SP) on
atherosclerotic human coronary arteries was studied. METHODS AND RESULTS [125I]-SP …

The endothelium-dependent vasodilator substance P dilates normal and diseased coronary
vessels in humans in vivo and produces a maximal response similar to that seen with …

Negative chronotropic and vasodilator responses of the isolated perfused guinea pig heart
to substance P (SP) were evaluated. Bolus injections of 2.5, 25 and 125 nmol of SP caused …

METHODS Apparently healthy dogs, unselected by age, breed, or sex, were premedicated
with morphine sulphate (3 mg/kg) subcutaneously; 1 hr later they were anaesthetized by the …

Highly purified substance P preparations were infused intravenously in doses of 0.2‐1.2
units per kg body weight per min in six healthy subjects. Red flushing, tachycardia and a …

It has been shown that substance P causes endothelium-dependent vasodilation in the
human coronary and forearm vessels. However, the precise mechanism whereby substance …

In dogs anaesthetised with chloralose, infusion of synthetic substance P into the femoral
artery caused marked elevation of femoral arterial blood flow which was well sustained …

The objective of this study was to determine if endothelium-dependent vasodilation is
preserved in the spastic segment of the epicardial coronary artery. Segmental responses of …

Objective. This study was designed to examine whether patients with coronary spastic
angina have an impaired coronary artery dilator response to substance P, an endothelium …