Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target

R Liu, S Du, L Zhao, S Jain, K Sahay… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by destruction of the myelin sheath structure. The loss of myelin leads …

Innate lymphoid cells-neglected players in multiple sclerosis

N Sadeghi Hassanabadi, B Broux, S Marinović… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a highly debilitating autoimmune disease affecting millions of
individuals worldwide. Although classically viewed as T-cell mediated disease, the role of …

Deleterious versus protective autoimmunity in multiple sclerosis

M Kostic, I Stojanovic, G Marjanovic, N Zivkovic… - Cellular …, 2015 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disorder of central
nervous system, in which myelin specific CD4+ T cells have a central role in orchestrating …

Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis

F Jadidi-Niaragh, A Mirshafiey - Immunopharmacology and …, 2011 - Taylor & Francis
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous
system characterized by perivascular inflammation and demyelination and loss of …

Inflammation in multiple sclerosis

S Haase, RA Linker - Therapeutic advances in neurological …, 2021 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) that is characterised pathologically by demyelination, gliosis, neuro-axonal damage …

Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies

P Stinissen, J Raus, J Zhang - Critical Reviews™ in …, 1997 - dl.begellhouse.com
Accumulating evidence indicates that multiple sclerosis (MS) is an autoimmune disease
mediated by autoreactive T lymphocytes with specificity for myelin antigens. Initially, the …

Emerging immunopharmacological targets in multiple sclerosis

M Farjam, GX Zhang, B Ciric, A Rostami - Journal of the neurological …, 2015 - Elsevier
Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple
sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals …

Circulating immune cells in multiple sclerosis

AP Jones, AG Kermode, RM Lucas… - Clinical & …, 2017 - academic.oup.com
Circulating T and B lymphocytes contribute to the pathogenesis of the neuroinflammatory
autoimmune disease, multiple sclerosis (MS). Further progress in the development of MS …

Role of regulatory T cells in pathogenesis and biological therapy of multiple sclerosis

M Buc - Mediators of inflammation, 2013 - Wiley Online Library
Multiple sclerosis (MS) is an inflammatory disease in which the myelin sheaths around the
axons of the brain and spinal cord are damaged, leading to demyelination and scarring as …

Cell-based modulation of autoimmune responses in multiple sclerosis and experimental autoimmmune encephalomyelitis: therapeutic implications

V Mastorodemos, M Ioannou, P Verginis - Neuroimmunomodulation, 2015 - karger.com
Multiple sclerosis (MS) is a prototypic autoimmune inflammatory disorder of the central
nervous system (CNS). MS pathogenesis is a complex phenomenon that is influenced by …