New oral anticoagulants in patients with nonvalvular atrial fibrillation: a review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness

H Mani, E Lindhoff-Last - Drug design, development and therapy, 2014 - Taylor & Francis
Atrial fibrillation (AF) continues to be a leading cause of cerebrovascular morbidity and
mortality resulting from cardioembolic stroke. Oral anticoagulation therapy has been shown …

Use of novel oral anticoagulants for patients with atrial fibrillation: systematic review and clinical implications

NM Albert - Heart & Lung, 2014 - Elsevier
Atrial fibrillation (AF), a common arrhythmia, increases the risk of ischemic stroke. Stroke and
bleeding scores for patients with AF can help to stratify risk and determine the need for …

The pharmacology of novel oral anticoagulants

TA DeWald, RC Becker - Journal of thrombosis and thrombolysis, 2014 - Springer
Anticoagulation for the prevention of stroke is an important aspect of the management of
atrial fibrillation. Novel anticoagulants including oral factor Xa inhibitors rivaroxaban and …

Practical considerations for using novel oral anticoagulants in patients with atrial fibrillation

I Savelieva, AJ Camm - Clinical cardiology, 2014 - Wiley Online Library
Novel oral anticoagulants, including dabigatran, rivaroxaban, and apixaban, represent new
options for preventing stroke in patients with atrial fibrillation, as shown by the results from …

Novel oral anticoagulants in non-valvular atrial fibrillation

R MFL da Silva - Cardiovascular & Hematological Agents in …, 2014 - ingentaconnect.com
Atrial fibrillation is the most frequent arrhythmia in clinical practice, reaching 2% of the
people in the world and is associated with systemic embolism. Thus, the use of …

New antithrombotics for atrial fibrillation

LRE Bereznicki, GM Peterson - Cardiovascular therapeutics, 2010 - Wiley Online Library
Atrial fibrillation (AF) is the most commonly occurring arrhythmia, and is a condition of both
significant clinical and economic importance. An antithrombotic agent is considered …

New oral anticoagulants for atrial fibrillation: a review of clinical trials

KM O'Dell, D Igawa, J Hsin - Clinical therapeutics, 2012 - Elsevier
BACKGROUND: Warfarin had been the only oral anticoagulant for stroke prevention in
patients with atrial fibrillation (AF) for decades. Direct thrombin inhibitors and factor Xa …

[HTML][HTML] Direct oral anticoagulants for the prevention of stroke in patients with nonvalvular atrial fibrillation: understanding differences and similarities

PP Dobesh, J Fanikos - Drugs, 2015 - Springer
The presence of atrial fibrillation (AF), the most common sustained cardiac arrhythmia,
significantly increases the risk for stroke. Current guidelines recommend that the vitamin K …

Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation

CS Miller, SM Grandi, A Shimony, KB Filion… - The American journal of …, 2012 - Elsevier
New oral anticoagulants, including apixaban, dabigatran, and rivaroxaban, have been
developed as alternatives to warfarin, the standard oral anticoagulation therapy for patients …

Novel anticoagulants for stroke prevention in atrial fibrillation: current clinical evidence and future developments

SH Schirmer, M Baumhäkel, HR Neuberger… - Journal of the American …, 2010 - jacc.org
Atrial fibrillation (AF) is the most common cardiac rhythm disorder and a major risk factor for
ischemic stroke. Antithrombotic therapy using aspirin or vitamin K antagonists (VKA) is …