Understanding antimicrobial resistance using genome-scale metabolic modeling

T Alonso-Vásquez, M Fondi, E Perrin - Antibiotics, 2023 - mdpi.com
The urgent necessity to fight antimicrobial resistance is universally recognized. In the search
of new targets and strategies to face this global challenge, a promising approach resides in …

[HTML][HTML] Genome-scale metabolic modeling in antimicrobial pharmacology

Y Zhu, J Zhao, J Li - Engineering Microbiology, 2022 - Elsevier
The increasing antimicrobial resistance has seriously threatened human health worldwide
over the last three decades. This severe medical crisis and the dwindling antibiotic discovery …

Novel antimicrobial development using genome-scale metabolic model of Gram-negative pathogens: a review

WY Chung, Y Zhu, MH Mahamad Maifiah… - The Journal of …, 2021 - nature.com
Antimicrobial resistance (AMR) threatens the effective prevention and treatment of a wide
range of infections. Governments around the world are beginning to devote effort for …

Use of constraint-based modeling for the prediction and validation of antimicrobial targets

JD Trawick, CH Schilling - Biochemical pharmacology, 2006 - Elsevier
The overall process of antimicrobial drug discovery and development seems simple, to cure
infectious disease by identifying suitable antibiotic drugs. However, this goal has been …

Metabolic modeling to interrogate microbial disease: a tale for experimentalists

F Jean-Pierre, MA Henson, GA O'Toole - Frontiers in Molecular …, 2021 - frontiersin.org
The explosion of microbiome analyses has helped identify individual microorganisms and
microbial communities driving human health and disease, but how these communities …

Systems biology: new insight into antibiotic resistance

P Francine - Microorganisms, 2022 - mdpi.com
Over the past few decades, antimicrobial resistance (AMR) has emerged as an important
threat to public health, resulting from the global propagation of multidrug-resistant strains of …

Genome-scale metabolic models as platforms for identification of novel genes as antimicrobial drug targets

BS Mienda, R Salihu, A Adamu, S Idris - Future microbiology, 2018 - Taylor & Francis
The growing number of multidrug-resistant pathogenic bacteria is becoming a world leading
challenge for the scientific community and for public health. However, advances in high …

Applications of system-level models of metabolism for analysis of bacterial physiology and identification of new drug targets

A Navid - Briefings in functional genomics, 2011 - academic.oup.com
For nearly all of the 20th century, biologists gained considerable insights into the
fundamental principles of cellular dynamics by examining select modules of biochemical …

A systems biology approach to studying the role of microbes in human health

I Thiele, A Heinken, RMT Fleming - Current opinion in biotechnology, 2013 - Elsevier
Host–microbe interactions play a crucial role in human health and disease. Of the various
systems biology approaches, reconstruction of genome-scale metabolic networks combined …

Mechanistic models of microbial community metabolism

LR Dillard, DD Payne, JA Papin - Molecular Omics, 2021 - pubs.rsc.org
Microbial communities affect many facets of human health and well-being. Naturally
occurring bacteria, whether in nature or the human body, rarely exist in isolation. A deeper …