Understanding antimicrobial resistance using genome-scale metabolic modeling
T Alonso-Vásquez, M Fondi, E Perrin - Antibiotics, 2023 - mdpi.com
The urgent necessity to fight antimicrobial resistance is universally recognized. In the search
of new targets and strategies to face this global challenge, a promising approach resides in …
of new targets and strategies to face this global challenge, a promising approach resides in …
[HTML][HTML] Genome-scale metabolic modeling in antimicrobial pharmacology
The increasing antimicrobial resistance has seriously threatened human health worldwide
over the last three decades. This severe medical crisis and the dwindling antibiotic discovery …
over the last three decades. This severe medical crisis and the dwindling antibiotic discovery …
Novel antimicrobial development using genome-scale metabolic model of Gram-negative pathogens: a review
WY Chung, Y Zhu, MH Mahamad Maifiah… - The Journal of …, 2021 - nature.com
Antimicrobial resistance (AMR) threatens the effective prevention and treatment of a wide
range of infections. Governments around the world are beginning to devote effort for …
range of infections. Governments around the world are beginning to devote effort for …
Use of constraint-based modeling for the prediction and validation of antimicrobial targets
JD Trawick, CH Schilling - Biochemical pharmacology, 2006 - Elsevier
The overall process of antimicrobial drug discovery and development seems simple, to cure
infectious disease by identifying suitable antibiotic drugs. However, this goal has been …
infectious disease by identifying suitable antibiotic drugs. However, this goal has been …
Metabolic modeling to interrogate microbial disease: a tale for experimentalists
The explosion of microbiome analyses has helped identify individual microorganisms and
microbial communities driving human health and disease, but how these communities …
microbial communities driving human health and disease, but how these communities …
Systems biology: new insight into antibiotic resistance
P Francine - Microorganisms, 2022 - mdpi.com
Over the past few decades, antimicrobial resistance (AMR) has emerged as an important
threat to public health, resulting from the global propagation of multidrug-resistant strains of …
threat to public health, resulting from the global propagation of multidrug-resistant strains of …
Genome-scale metabolic models as platforms for identification of novel genes as antimicrobial drug targets
The growing number of multidrug-resistant pathogenic bacteria is becoming a world leading
challenge for the scientific community and for public health. However, advances in high …
challenge for the scientific community and for public health. However, advances in high …
Applications of system-level models of metabolism for analysis of bacterial physiology and identification of new drug targets
A Navid - Briefings in functional genomics, 2011 - academic.oup.com
For nearly all of the 20th century, biologists gained considerable insights into the
fundamental principles of cellular dynamics by examining select modules of biochemical …
fundamental principles of cellular dynamics by examining select modules of biochemical …
A systems biology approach to studying the role of microbes in human health
Host–microbe interactions play a crucial role in human health and disease. Of the various
systems biology approaches, reconstruction of genome-scale metabolic networks combined …
systems biology approaches, reconstruction of genome-scale metabolic networks combined …
Mechanistic models of microbial community metabolism
Microbial communities affect many facets of human health and well-being. Naturally
occurring bacteria, whether in nature or the human body, rarely exist in isolation. A deeper …
occurring bacteria, whether in nature or the human body, rarely exist in isolation. A deeper …
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