Summary β-adrenergic receptors (β-ARs), prototypic G-protein-coupled receptors (GPCRs),
play a critical role in regulating numerous physiological processes. The GPCR kinases …

GRK2 is a member of the G protein-coupled receptor kinase (GRK) family, which
phosphorylates the activated form of a variety of G protein-coupled receptors (GPCR) and …

G protein-coupled receptor kinase (GRK)-mediated receptor phosphorylation and β-arrestin
binding uncouple G protein-coupled receptors (GPCRs) from their respective G proteins and …

G protein-coupled receptor kinases (GRKs) specifically recognize and phosphorylate the
hormone-occupied form of numerous G protein-coupled receptors, ultimately resulting in …

Agonist-dependent activation of G protein-coupled receptors induces diversified receptor
cellular and signaling properties. Norepinephrine (NE) and epinephrine (Epi) are two …

A variety of G protein-coupled receptors (GPCRs) are phosphorylated by G protein-coupled
receptor kinase 2 (GRK2). This event promotes the binding of regulatory proteins termed β …

Agonist-dependent regulation of G protein-coupled receptors is dependent on their
phosphorylation by G protein-coupled receptor kinases (GRKs). GRK2 and GRK3 are …

The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR
kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated …

G protein-coupled receptor kinases (GRKs) specifically phosphorylate activated G protein-
coupled receptors. While the X-ray crystal structures of several GRKs have been …

G protein-coupled receptor kinases (GRKs) mediate desensitization of agonist-occupied G
protein-coupled receptors (GPCRs). Here we report that GRK5 contains a DNA-binding …