Quantitative proteomics based bioactive proteins discovery and quality control of medicinal leeches
FG Li, XY Shi, L Yang, X Lu, Y Qi, P Li, H Yang… - Journal of …, 2024 - Elsevier
Highlights•17 batches of commercial leeches were identified using DNA barcoding based
on COI gene.•A total of 1035 proteins were identified from 3 species leeches.•90 co-existed …
on COI gene.•A total of 1035 proteins were identified from 3 species leeches.•90 co-existed …
Characterization of the natural peptidome of four leeches by integrated proteogenomics and pseudotargeted peptidomics
J Liao, M Gao, Y Ding, Q Bi, D Huang, X Luo… - Analytical and …, 2023 - Springer
Animal-derived drugs are an indispensable part of folk medicine worldwide. However, their
chemical constituents are poorly approached, which leads to the low level of the quality …
chemical constituents are poorly approached, which leads to the low level of the quality …
In-depth profiles of bioactive large molecules in saliva secretions of leeches determined by combining salivary gland proteome and transcriptome data
Z Liu, X Tong, Y Su, D Wang, X Du, F Zhao, D Wang… - Journal of …, 2019 - Elsevier
Medicinal leeches have been widely utilized in medical procedures for thousands of years.
The application of leeches depends on the components of leech saliva secretions and active …
The application of leeches depends on the components of leech saliva secretions and active …
Application for proteomics analysis technology in studying animal-derived traditional Chinese medicine: A review
X Tang, J Guo, L Chen, PCL Ho - Journal of Pharmaceutical and …, 2020 - Elsevier
Different therapeutically active ingredients, from plants, animals, and mineral sources, are
prescribed as traditional Chinese medicines (TCM). TCMs, from animal sources, are rich in …
prescribed as traditional Chinese medicines (TCM). TCMs, from animal sources, are rich in …
Transcriptomic analysis of the salivary gland of medicinal leech Hirudo nipponia
Z Lu, P Shi, H You, Y Liu, S Chen - PLoS One, 2018 - journals.plos.org
Hirudo nipponia (known as Shui Zhi in Chinese) is a well-known Chinese medicine with
numerous active ingredients in its body, especially in its saliva. This native Chinese blood …
numerous active ingredients in its body, especially in its saliva. This native Chinese blood …
Functional screening of serine protease inhibitors in the medical leech Hirudo medicinalis monitored by intensity fading MALDI-TOF MS
The blood-feeding invertebrates are a rich biological source of drugs and lead compounds
to treat cardiovascular diseases because they have evolved highly efficient mechanisms to …
to treat cardiovascular diseases because they have evolved highly efficient mechanisms to …
Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains
J Ebner, AA Arslan, M Fedorova, R Hoffmann… - Journal of …, 2015 - Elsevier
Kefir has a long tradition in human nutrition due to its presupposed health promoting effects.
To investigate the potential contribution of bioactive peptides to the physiological effects of …
To investigate the potential contribution of bioactive peptides to the physiological effects of …
Discovery of novel drug targets and their functions using phenotypic screening of natural products
J Chang, HJ Kwon - Journal of Industrial Microbiology and …, 2016 - academic.oup.com
Natural products are valuable resources that provide a variety of bioactive compounds and
natural pharmacophores in modern drug discovery. Discovery of biologically active natural …
natural pharmacophores in modern drug discovery. Discovery of biologically active natural …
Comparative analysis of the main active constituents from different parts of Leonurus japonicus Houtt. and from different regions in China by ultra-high performance …
YJ Tan, DQ Xu, SJ Yue, YP Tang, S Guo, H Yan… - … of pharmaceutical and …, 2020 - Elsevier
A rapid, sensitive and convenient analytical method of ultra-performance liquid
chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry …
chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry …
Global proteomic analysis of Chelidonium majus and Corydalis cava (Papaveraceae) extracts revealed similar defense-related protein compositions
R Nawrot, H Zauber, WX Schulze - Fitoterapia, 2014 - Elsevier
Chelidonium majus and Corydalis cava are phylogenetically closely related (Papaveraceae
family). The medicinal and pharmaceutical interest in these plants is based on their …
family). The medicinal and pharmaceutical interest in these plants is based on their …