Objectives To determine the feasibility (as measured by tolerability and safety) and efficacy
of topical 5‐fluorouracil (5‐FU) and imiquimod for the treatment of cervical intraepithelial …

Abstract Current management of Cervical Intraepithelial Neoplasia (CIN), caused by high-
risk human papillomavirus (hr-HPV), is based on surveillance and surgical therapy …

Background Cervical cancer is a major public health issue in the world, especially in
developing countries. It can be prevented through vaccination against HPV (primary …

Objective The objective of the study was to evaluate the efficacy of intravaginal application of
5% 5-fluorouracil (5-FU) for the treatment of cervical intraepithelial neoplasia (CIN) 2 in …

OBJECTIVE: Alternatives to surgical therapy are needed for the treatment of high-grade
cervical intraepithelial neoplasia (CIN 2–3). We aimed to estimate the efficacy of a treatment …

OBJECTIVE: To evaluate the histologic response rate of high-grade squamous
intraepithelial lesions (HSIL) of the cervix after topical application of 5% imiquimod cream …

Topical imiquimod could be an alternative, noninvasive, treatment modality for high-grade
cervical intraepithelial neoplasia (CIN). However, evidence is limited, and there are no …

Background Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical
cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural …

(1) Background: There are limited data on the success of conservative treatment of high-
grade cervical squamous intraepithelial lesions (HSIL) with imiquimod directly compared to …

Abstract The “TOPical Imiquimod treatment of high-grade Cervical intraepithelial
neoplasia”(TOPIC) trial was stopped preliminary, due to lagging inclusions. This study …