As the largest known family of cell surface receptors and the most common therapeutic drug
targets, G protein-coupled receptors (GPCRs) are at the center of modern medicine. Multiple …

G protein-coupled receptors (GPCRs), which regulate a vast number of eukaryotic
processes, are desensitized by various mechanisms but, most importantly, by the GPCR …

G protein-coupled receptor kinases (GRKs) are key modulators of G protein-coupled
receptor (GPCR) signaling. They constitute a family of seven mammalian serine-threonine …

Six vertebrate protein kinases (G‐protein‐coupled receptor kinases; GRKs) that regulate the
function of G‐protein‐coupled receptors (GPCRs) were recently cloned; several distinct …

A unifying mechanism by which G protein–coupled receptors (GPCRs) signal in cell type–
dependent and G protein–independent ways has developed over the past decade. GPCR …

This review is provided in recognition of the extensive contributions of Dr. Robert J.
Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday …

G protein coupled receptor (GPCR) signalling is mediated by transactivation independent
and transactivation dependent pathways. GPCRs transactivate protein tyrosine kinase …

G protein-coupled receptors (GPCRs) can utilize receptor tyrosine kinases (RTKs) to
mediate important cellular responses such as proliferation, differentiation and survival …

G protein-coupled receptor kinases (GRKs) phosphorylate agonist-occupied receptors
initiating the processes of desensitization and β-arrestin-dependent signaling. Interaction of …

Almost all G‐protein coupled receptors (GPCRs) are regulated by phosphorylation and this
process is a key event in determining the signalling properties of this receptor super‐family …