Simulating chromatin is crucial for predicting genome organization and dynamics. Although
coarse-grained bead-spring polymer models are commonly used to describe chromatin, the …

Chromatin can be viewed as a hierarchically structured fiber that regulates gene expression.
It consists of a complex network of DNA and proteins whose characteristic dynamical modes …

The dynamic organization of chromatin plays an essential role in the regulation of gene
expression and in other fundamental cellular processes. The underlying physical basis of …

Background DNA inside eukaryotic cells wraps around histones to form the 11nm chromatin
fiber that can further fold into higher-order DNA loops, which may depend on the binding of …

The hierarchical packaging of DNA into chromatin within a eukaryotic nucleus plays a
pivotal role in both the accessibility of genomic information and the dynamics of replication …

We present a physics-based polymer model that can investigate 3D organization of
chromatin accounting for DNA elasticity, DNA-bending due to nucleosomes, and 1D …

The 3D organization of chromosomes is crucial for regulating gene expression and cell
function. Many experimental and polymer modeling efforts are dedicated to deciphering the …

The spatial organization of chromosomes has key functional roles, yet how chromosomes
fold remains poorly understood at the single-molecule level. Here, we employ models of …

To elucidate conformational dynamics of chromatin fibers, we compared available force-
spectroscopy measurements with extensive Monte Carlo simulations of nucleosome arrays …

Interactions of chromatin with the nuclear lamina imposes a radial genome distribution
important for nuclear functions. How physical properties of chromatin affect these …