DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

P Issarapu, M Arumalla, HR Elliott… - Nature …, 2023 - nature.com
Human height is strongly influenced by genetics but the contribution of modifiable epigenetic
factors is under-explored, particularly in low and middle-income countries (LMIC). We …

Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity

O Ali, D Cerjak, JW Kent Jr, R James, J Blangero… - Epigenetics, 2016 - Taylor & Francis
Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene
and environment and may play an important role in the obesity epidemic. We assessed the …

DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults

LS Glover, AG Lilly, AE Justice… - Human Molecular …, 2024 - academic.oup.com
Obesity and poverty disproportionally affect African American persons. Epigenetic
mechanisms could partially explain the association between socioeconomic disadvantage …

Associations between epigenome-wide DNA methylation and height-related traits among Sub-Saharan Africans: the RODAM study

G Swart, K Meeks, F Chilunga, A Venema… - … origins of health and …, 2023 - cambridge.org
Human height and related traits are highly complex, and extensively research has shown
that these traits are determined by both genetic and environmental factors. Such factors may …

Adult height variants affect birth length and growth rate in children

L Paternoster, LD Howe, K Tilling… - Human molecular …, 2011 - academic.oup.com
Previous studies identified 180 single nucleotide polymorphisms (SNPs) associated with
adult height, explaining∼ 10% of the variance. The age at which these begin to affect …

Epigenetic heredity of human height

P Simeone, S Alberti - Physiological reports, 2014 - Wiley Online Library
Genome‐wide SNP analyses have identified genomic variants associated with adult human
height. However, these only explain a fraction of human height variation, suggesting that …

Socioeconomic status and DNA methylation from birth through mid-childhood: a prospective study in Project Viva

ZM Laubach, W Perng, A Cardenas… - …, 2019 - Taylor & Francis
Aim: We investigated associations of prenatal socioeconomic status (SES) with DNA
methylation at birth, and to explore persistence of associations into early (∼3 years) and …

Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth

R Alfano, D Zugna, H Barros, M Bustamante, L Chatzi… - BMC medicine, 2023 - Springer
Background Rapid postnatal growth may result from exposure in utero or early life to
adverse conditions and has been associated with diseases later in life and, in particular …

Association between DNA methylation at SOCS3 gene and body mass index might be due to familial confounding

S Li, EM Wong, MC Southey, JL Hopper - International Journal of …, 2017 - nature.com
Wilson et al. 1 found, from cross-sectional analyses of data for middle-aged women from the
Sister Study cohort, that DNA methylation in blood at nine CpG sites was associated with …

Socioeconomic position during pregnancy and DNA methylation signatures at three stages across early life: epigenome-wide association studies in the ALSPAC birth …

R Alfano, F Guida, B Galobardes… - International journal …, 2019 - academic.oup.com
Background Socioeconomic experiences are recognized determinants of health, and recent
work has shown that social disadvantages in early life may induce sustained biological …