The impact of the opioid epidemic on pregnant people and children is a growing public
health crisis. Understanding how opioids affect the developing brain during pregnancy and …

The overall prevalence of opiate use has been increasing, currently affecting approximately
0.6% of the global population and resulting in a significant proportion of infants being born …

The opioid epidemic has adversely affected neonates and children, yet the mechanisms by
which it impacts this population are not well understood. Not only does prenatal opioid …

Background Preclinical data demonstrate that opioids modulate brain reward signaling
through an inflammatory cascade, but this relationship has yet to be studied in opioid …

Aim This systematic review aims to estimate the relationship between prenatal exposure to
opioids and neurodevelopmental outcomes and examines potential sources of …

Background Prenatal opioid exposure has been associated with developmental deficits
during infancy, but the literature is limited by simple group comparisons and lack of …

The developmental impact of opioid use during pregnancy is a subject of ongoing debate.
Short-term neonatal outcomes, such as lower birth weight and neonatal abstinence …

Background Prenatal opioid exposure has been linked to adverse birth outcomes and
delays in infant development. Existing literature is limited by a simple group-differences …

Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per 1000
births in 2000 to 5.8 per 1000 births in 2012. Symptoms in neonates may include high …

The opioid epidemic in the United States has resulted in a significant increase in opioid use
disorder among pregnant women and a concomitant increase in the incidence of neonatal …