Cervical high-grade squamous intraepithelial lesions (cHSILs) develop as a result of a
persistent high-risk human papilloma virus (hrHPV) infection. The natural course of cHSIL is …

The activation of HPV-specific T cells within the cervical microenvironment is likely to play an
important part in the natural history of cervical intraepithelial neoplasia (CIN). The extent and …

Introduction Immunological competence influences the progression of cervical intraepithelial
neoplasia (CIN) to invasive cancer. Information on the local immunological changes during …

Background and aims 15–30% of cases of cervical intraepithelial neoplasia grades 2–3
(CIN2–3) detected in punch biopsies regress spontaneously (ie, show CIN1 or less in the …

Problem Local adaptive cervical regulatory T cells (Tregs) are the most likely direct
suppressors of the immune eradication of cervical intraepithelial lesion (CIN). PD‐1 …

Triage of the abnormal Papanicolaou (Pap) smear involves differentiating low-grade
squamous intraepithelial lesions (LGSIL), highgrade squamous intraepithelial lesions …

Background Most infections with human papillomavirus (HPV) are resolved without clinical
intervention, but a minority evolves into chronic lesions of distinct grades, including cervical …

Strong evidence exists that the host's immune system plays a crucial role for the
development of human papillomavirus‐related cervical premalignant and malignant lesions …

Background The complete response rate of cervical high-grade squamous intraepithelial
lesion (cHSIL) patients to imiquimod immunotherapy is approximately 60%. Consequently …

We have addressed the notion that the initiation and progression of human papillomavirus
associated cancer of the uterine cervix are associated with alterations of Langerhans cells …