[HTML][HTML] Diosmetin reduces bone loss and osteoclastogenesis by regulating the expression of TRPV1 in osteoporosis rats

S Hu, Y Huang, Y Chen, R Zhou, X Yang… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Osteoporosis is a systemic skeletal disorder and occurs frequently in
postmenopausal women and older men. This study aimed to examine whether diosmetin …

Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis

X Tao, Y Qi, L Xu, L Yin, X Han, Y Xu, C Wang… - Pharmacological …, 2016 - Elsevier
Our previous studies showed that dioscin can promote osteoblasts proliferation and
differentiation in vitro, but its anti-osteoporosis effect in vivo and the underlying mechanisms …

Diosmetin inhibits osteoclast formation and differentiation and prevents LPS‐induced osteolysis in mice

S Shao, F Fu, Z Wang, F Song, C Li… - Journal of Cellular …, 2019 - Wiley Online Library
Osteolytic bone diseases are closely linked to the over‐activation of osteoclasts and
enhancement of bone resorption. It has become a major health issue in orthopedic practice …

[HTML][HTML] Diosmin mitigates dexamethasone-induced osteoporosis in vivo: Role of Runx2, RANKL/OPG, and oxidative stress

ESA Arafa, NO Elgendy, MA Elhemely… - Biomedicine & …, 2023 - Elsevier
Secondary osteoporosis is commonly caused by long-term intake of glucocorticoids (GCs),
such as dexamethasone (DEX). Diosmin, a natural substance with potent antioxidant and …

Trilobatin ameliorates bone loss via suppression of osteoclast cell differentiation and bone resorptive function in vitro and in vivo

SC Kim, HJ Kim, GE Park, RP Pandey, J Lee, JK Sohng… - Life Sciences, 2021 - Elsevier
Aim Due to on-going safety concerns or lack of efficacy of currently used medications for the
treatment of osteoporosis (OP), identifying new therapeutic agents is an important part of …

Dioscin improves postmenopausal osteoporosis through inducing bone formation and inhibiting apoptosis in ovariectomized rats

S Wu, F Zhao, J Zhao, H Li, J Chen, Y Xia, J Wang… - Bioscience …, 2019 - jstage.jst.go.jp
Postmenopausal osteoporosis (PMO) has become a public health problem worldwide.
Hormonal replacement therapy (HRT) is the most popular treatment for PMO at present, but …

Synergistic protective effects of resveratrol and estradiol on estrogen deficiency-induced osteoporosis through attenuating rank pathway.

BH Elesawy, HF Sakr, AM Abbas - 2021 - cabidigitallibrary.org
Abstract Background and Objective: Loss of ovarian function after menopause affects bone
metabolism and structure. The present study examined the synergistic effects of Estradiol …

Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITG β3 signaling pathway

Q Wei, MH Ouyang, X Guo, X Fu, T Liu, Y Luo… - European Journal of …, 2024 - Elsevier
Osteoporosis is a highly prevalent bone metabolic disease in menopause due to estrogen
deficiency. Hyperoside is a main compound in Semen cuscutae. Our team previously …

Mechanism of dexmedetomidine regulating osteogenesis-angiogenesis coupling through the miR-361-5p/VEGFA axis in postmenopausal osteoporosis

Z Wang, X Ge, Y Wang, Y Liang, H Shi, T Zhao - Life sciences, 2021 - Elsevier
Aims Postmenopausal osteoporosis (PMOP) is a growing health problem affecting many
postmenopausal women. This study intended to identify the role of dexmedetomidine (Dex) …

[HTML][HTML] Secoisolariciresinol diglucoside regulates estrogen receptor expression to ameliorate OVX-induced osteoporosis

G Chen, Y Chen, J Hong, J Gao, Z Xu - Journal of Orthopaedic Surgery …, 2023 - Springer
Objective Secoisolariciresinol diglucoside (SDG) is a phytoestrogen that has been reported
to improve postmenopausal osteoporosis (PMOP) caused by estrogen deficiency. In our …