SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway
Z Chen, Z Jiang, L Meng, Y Wang, M Lin, Z Wei… - Cell Cycle, 2022 - Taylor & Francis
ABSTRACT SAMHD1 was reported to be related with the development of tumors, while its
function in gastric cancer (GC) has not been elucidated yet. Here, we investigated the role …
function in gastric cancer (GC) has not been elucidated yet. Here, we investigated the role …
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs
Z Chen, J Hu, S Ying, A Xu - Oncology Letters, 2021 - spandidos-publications.com
Human sterile alpha motif and HD‑domain‑containing protein 1 (SAMHD1) has been
identified as a GTP or dGTP‑dependent deoxynucleotide triphosphohydrolase (dNTPase) …
identified as a GTP or dGTP‑dependent deoxynucleotide triphosphohydrolase (dNTPase) …
Expression of SAMHD1 and its mutation on prognosis of colon cancer
Z Zhang, P Li, P Sun - Oncology Letters, 2022 - spandidos-publications.com
The expression of sterile α motif and histidine/aspartic acid domain‑containing protein 1
(SAMHD1) and its mutation play a key role in the prognosis of colon cancer. The aim of the …
(SAMHD1) and its mutation play a key role in the prognosis of colon cancer. The aim of the …
[HTML][HTML] SAMHD1 can suppress lung adenocarcinoma progression through the negative regulation of STING
Y Wu, Y Niu, Y Wu, X Chen, X Shen… - Journal of Thoracic …, 2021 - ncbi.nlm.nih.gov
Background The sterile alpha motif (SAM) domain and histidine-aspartate (HD) domain-
containing protein 1 (SAMHD1) has been specifically linked to lung cancer. However, the …
containing protein 1 (SAMHD1) has been specifically linked to lung cancer. However, the …
SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis
KM Kodigepalli, S Bonifati, N Tirumuru, L Wu - Cell Cycle, 2018 - Taylor & Francis
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP
hydrolase that acts as a negative regulator in the efficacy of cytarabine treatment against …
hydrolase that acts as a negative regulator in the efficacy of cytarabine treatment against …
Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells
Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP
hydrolase (dNTPase) that regulates intracellular dNTP balance. We have previously …
hydrolase (dNTPase) that regulates intracellular dNTP balance. We have previously …
SAMHD1 as a prognostic and predictive biomarker in stage II colorectal cancer: A multicenter cohort study
D You, S Zhang, S Yan, Y Ding, C Li, X Cheng… - Frontiers in …, 2022 - frontiersin.org
Background The identification of high-risk population patients is key to the personalized
treatment options for the stage II colorectal cancers. The use of proteomics in the prognosis …
treatment options for the stage II colorectal cancers. The use of proteomics in the prognosis …
SAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer
L Gutiérrez-Chamorro, E Felip, E Castellà, V Quiroga… - Cellular Oncology, 2024 - Springer
Purpose The lack of validated surrogate biomarkers is still an unmet clinical need in the
management of early breast cancer cases that do not achieve complete pathological …
management of early breast cancer cases that do not achieve complete pathological …
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis
L Gutiérrez-Chamorro, E Felip… - Frontiers in …, 2023 - frontiersin.org
Purpose SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase which
has been proposed as a putative prognostic factor in haematological cancers and certain …
has been proposed as a putative prognostic factor in haematological cancers and certain …
SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a mammalian dNTP
hydrolase (dNTPase) and functions as a negative regulator in the efficacy of cytarabine …
hydrolase (dNTPase) and functions as a negative regulator in the efficacy of cytarabine …