Estimates of the minimal important difference to evaluate the clinical significance of antidepressants in the acute treatment of moderate-to-severe depression
MP Hengartner, M Plöderl - BMJ Evidence-Based Medicine, 2022 - ebm.bmj.com
The efficacy of antidepressants in the acute treatment of moderate-to-severe depression
remains a controversial issue. The minimal important difference (MID) is relevant to judge …
remains a controversial issue. The minimal important difference (MID) is relevant to judge …
Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg Depression Rating Scale, the gold standard clinician rating scale: A meta-analysis …
Background It has been claimed that efficacy estimates based on the Hamilton Depression
Rating-Scale (HDRS) underestimate antidepressants true treatment effects due to the …
Rating-Scale (HDRS) underestimate antidepressants true treatment effects due to the …
Do antidepressants work? A commentary on “Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration” by …
RH McAllister-Williams - BMJ Ment Health, 2008 - mentalhealth.bmj.com
It is important to understand what the primary outcomes of the meta-analysis were and how
they were chosen. This relates to the authors' previous arguments in this area2 based …
they were chosen. This relates to the authors' previous arguments in this area2 based …
One (effect) size does not fit at all: interpreting clinical significance and effect sizes in depression treatment trials
F Hieronymus, S Jauhar… - Journal of …, 2020 - journals.sagepub.com
The efficacy of antidepressants in major depressive disorder has been continually
questioned, mainly on the basis of studies using the sum-score of the Hamilton Depression …
questioned, mainly on the basis of studies using the sum-score of the Hamilton Depression …
Randomized clinical trials underestimate the efficacy of antidepressants in less severe depression
G Isacsson, M Adler - Acta Psychiatrica Scandinavica, 2012 - Wiley Online Library
Isacsson G, Adler M. Randomized clinical trials underestimate the efficacy of
antidepressants in less severe depression. Objective: Demonstrating the superiority of …
antidepressants in less severe depression. Objective: Demonstrating the superiority of …
Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review
C Veal, A Tomlinson, A Cipriani, S Bulteau… - The Lancet …, 2024 - thelancet.com
Research waste occurs when randomised controlled trial (RCT) outcomes are
heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or …
heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or …
Minimally important differences and severity thresholds are estimated for the PROMIS depression scales from three randomized clinical trials
Abstract Background Patient Reported Outcomes Measurement Information Systems
(PROMIS) scales are increasingly being used to measure symptoms in research and …
(PROMIS) scales are increasingly being used to measure symptoms in research and …
Can effects of antidepressants in patients with mild depression be considered as clinically significant?
U Hegerl, AK Allgaier, V Henkel, R Mergl - Journal of affective disorders, 2012 - Elsevier
BACKGROUND: How to define clinical significance of antidepressants has become a matter
of far-reaching clinical and regulatory consequences. A mean difference of at least 3 points …
of far-reaching clinical and regulatory consequences. A mean difference of at least 3 points …
The clinical relevance of changes in the Montgomery–Asberg Depression Rating Scale using the minimum clinically important difference approach
G Duru, B Fantino - Current medical research and opinion, 2008 - Taylor & Francis
Objective: To identify the minimal clinically important difference (MCID) for the Montgomery–
Asberg Depression Rating Scale (MADRS) in randomised studies of depression, and to …
Asberg Depression Rating Scale (MADRS) in randomised studies of depression, and to …
What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A …
Objective Reanalyse the patient-level data set of the Sequenced Treatment Alternatives to
Relieve Depression (STAR* D) study with fidelity to the original research protocol and …
Relieve Depression (STAR* D) study with fidelity to the original research protocol and …