Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles
A Malyshkina, W Bayer, P Podschwadt, L Otto… - PLoS …, 2023 - journals.plos.org
Antiretroviral therapy (ART) transformed HIV from a life-threatening disease to a chronic
condition. However, eliminating the virus remains an elusive therapy goal. For several …
condition. However, eliminating the virus remains an elusive therapy goal. For several …
Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
A Malyshkina, E Littwitz-Salomon, K Sutter… - Cancer Immunology …, 2019 - Springer
T cell responses are crucial for anti-tumor immunity. In chronic viral infections, anti-tumor T
cell responses can be compromised due to various immunological mechanisms, including T …
cell responses can be compromised due to various immunological mechanisms, including T …
Human Immunodeficiency Virus Playing Hide-and-Seek: Understanding the TFH Cell Reservoir and Proposing Strategies to Overcome the Follicle Sanctuary
Human immunodeficiency virus (HIV) infects millions of people worldwide, and new cases
continue to emerge. Once infected, the virus cannot be cleared by the immune system and …
continue to emerge. Once infected, the virus cannot be cleared by the immune system and …
Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies
C Petrovas, S Ferrando-Martinez, MY Gerner… - Science translational …, 2017 - science.org
Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells
and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 …
and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 …
The B-cell follicle in HIV infection: barrier to a cure
MP Bronnimann, PJ Skinner, E Connick - Frontiers in immunology, 2018 - frontiersin.org
The majority of HIV replication occurs in secondary lymphoid organs (SLOs) such as the
spleen, lymph nodes, and gut-associated lymphoid tissue. Within SLOs, HIV RNA+ cells are …
spleen, lymph nodes, and gut-associated lymphoid tissue. Within SLOs, HIV RNA+ cells are …
Infection of B cell follicle-resident cells by Friend retrovirus occurs during acute infection and is maintained during viral persistence
S Windmann, L Otto, CP Hrycak, A Malyshkina… - MBio, 2019 - Am Soc Microbiol
ABSTRACT B cell follicles of the spleen and lymph nodes are immune privileged sites and
serve as sanctuaries for infected CD4+ cells in HIV infection. It is assumed that CD8+ T cell …
serve as sanctuaries for infected CD4+ cells in HIV infection. It is assumed that CD8+ T cell …
Differentiation and function of follicular CD8 T cells during human immunodeficiency virus infection
M Xiao, X Chen, R He, L Ye - Frontiers in Immunology, 2018 - frontiersin.org
The combination antiretroviral therapeutic (cART) regime effectively suppresses human
immunodeficiency virus (HIV) replication and prevents progression to acquired …
immunodeficiency virus (HIV) replication and prevents progression to acquired …
Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection
During chronic HIV infection, viral replication is concentrated in secondary lymphoid follicles.
Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle …
Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle …
Expansion of HIV-specific T follicular helper cells in chronic HIV infection
M Lindqvist, J Van Lunzen… - The Journal of …, 2012 - Am Soc Clin Investig
HIV targets CD4 T cells, which are required for the induction of high-affinity antibody
responses and the formation of long-lived B cell memory. The depletion of antigen-specific …
responses and the formation of long-lived B cell memory. The depletion of antigen-specific …
The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles
GM Webb, S Li, G Mwakalundwa, JM Folkvord… - Blood …, 2018 - ashpublications.org
Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely
exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to …
exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to …