Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …

Adult hippocampal neurogenesis plays a critical role in memory and emotion processing,
and this process is dynamically regulated by neural circuit activity. However, it remains …

Hippocampal neurogenesis is impaired in Alzheimer's disease (AD) patients and familial
Alzheimer's disease (FAD) mouse models. However, it is unknown whether new neurons …

Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Highlights•The number, maturation state, and activity of adult-born neurons contribute to
distinct aspects of hippocampal function.•Multi-level enhancement of hippocampal …

Deficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental,
psychiatric and neurodegenerative diseases. Genetic ablation of neurogenesis provides …

New neurons are abnormal in the adult hippocampus of Alzheimer's disease (AD) mouse
models. The effects of modulating adult neurogenesis on AD pathogenesis differ from study …

The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural
stem cells. Newborn neurons integrate into existing neuronal networks, where they play a …

Human Alzheimer's disease (AD) brains and transgenic AD mouse models manifest
hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that …

Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …