Oxygen (O2) is essential for life and therefore the supply of sufficient O2 to the tissues is a
major physiological challenge. In mammals, a deficit of O2 (hypoxia) triggers rapid …

Maintaining oxygen homeostasis is crucial to the survival of animals. Mammals respond
acutely to changes in blood oxygen levels by modulating cardiopulmonary function. The …

Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments
or medical conditions with restricted exchange of gases in the lung. The main acute O2 …

Acute O 2 sensing by peripheral chemoreceptors is essential for mammalian homeostasis.
Carotid body glomus cells contain O 2-sensitive ion channels, which trigger fast adaptive …

The mammalian carotid body (CB) is the primary arterial chemoreceptor that responds to
acute hypoxia, initiating systemic protective reflex responses that act to maintain O2 delivery …

Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and
integrate changes in several physical and chemical parameters in the blood. These cells are …

Mammalian carotid body arterial chemoreceptors function as an early warning system for
hypoxia, triggering acute life-saving arousal and cardiorespiratory reflexes. To serve this …

Hypoxia elicits a variety of adaptive responses at the tissue level, at the cellular level, and at
the molecular level. A physiological response to hypoxia requires the existence of an O2 …

Significance: Acute responses to hypoxia are essential for the survival of mammals. The
carotid body (CB), the main arterial chemoreceptor, contains glomus cells with oxygen (O2) …

Key points Glomus cells in the carotid body (CB) and chromaffin cells in the adrenal medulla
(AM) are essential for reflex cardiorespiratory adaptation to hypoxia. However, the …