Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and
help orchestrate the immune response. This family of cells can be separated by their nuclear …

Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …

The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

In humans, the monocyte pool comprises three subsets (classical, intermediate, and
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation …

Despite increasing longevity, many old people are not in good health. There has been an
increase in the prevalence of age-associated multi-morbidity (two or more chronic conditions …

The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and
dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability …

All immune cells are affected by aging, contributing to the high susceptibility to infections
and increased mortality observed in the elderly. The effect of aging on cells of the adaptive …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Aging results in increased myelopoiesis, which is linked to the increased incidence of
myeloid leukemias and production of myeloid-derived suppressor cells. Here, we examined …

Neutrophils are first-responders, providing early protection against invading pathogens.
Recent findings have revealed a temporal dimension to neutrophil function, associated with …