Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

RNA splicing, the enzymatic process of removing segments of premature RNA to produce
mature RNA, is a key mediator of proteome diversity and regulator of gene expression …

Cancer arises from alterations in several metabolic processes affecting proliferation, growth,
replication and death of cells. A fundamental challenge in the study of cancer biology is to …

Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Recently splicing has been recognized as a key pathway in cancer. Although aberrant
splicing has been shown to be a consequence of mutations or the abnormal expression of …

High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …

Alterations in the abundance or activities of alternative splicing regulators generate
alternatively spliced variants that contribute to multiple aspects of tumor establishment …

Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …

Alternative splicing is one of the most common mechanisms for gene regulation in humans,
and plays a vital role to increase the complexity of functional proteins. In this article, we seek …