[HTML][HTML] Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases
ZD Zhou, EK Tan - Molecular neurodegeneration, 2017 - Springer
The homeostasis of iron is vital to human health, and iron dyshomeostasis can lead to
various disorders. Iron homeostasis is maintained by iron regulatory proteins (IRP1 and …
various disorders. Iron homeostasis is maintained by iron regulatory proteins (IRP1 and …
Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease
The essential metals iron, zinc and copper deposit near the Aβ (amyloid β-peptide) plaques
in the brain cortex of AD (Alzheimer's disease) patients. Plaque-associated iron and zinc are …
in the brain cortex of AD (Alzheimer's disease) patients. Plaque-associated iron and zinc are …
[HTML][HTML] Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer's …
In addition to the devastating symptoms of dementia, Alzheimer's disease (AD) is
characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide …
characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide …
[HTML][HTML] Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1*♦
HH Cho, CM Cahill, CR Vanderburg… - Journal of Biological …, 2010 - ASBMB
Iron influx increases the translation of the Alzheimer amyloid precursor protein (APP) via an
iron-responsive element (IRE) RNA stem loop in its 5′-untranslated region. Equal …
iron-responsive element (IRE) RNA stem loop in its 5′-untranslated region. Equal …
Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains.
DJ Pinero, J Hu, JR Connor - Cellular and molecular biology (Noisy …, 2000 - europepmc.org
Iron regulatory proteins (IRPs) are cytoplasmic mRNA binding proteins involved in
intracellular regulation of iron homeostasis. IRPs regulate expression of ferritin and …
intracellular regulation of iron homeostasis. IRPs regulate expression of ferritin and …
Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome
G Costain, MC Ghosh, N Maio, A Carnevale, YC Si… - Brain, 2019 - academic.oup.com
Disruption of cellular iron homeostasis can contribute to neurodegeneration. In mammals,
two iron-regulatory proteins (IRPs) shape the expression of the iron metabolism proteome …
two iron-regulatory proteins (IRPs) shape the expression of the iron metabolism proteome …
Abnormal localization of iron regulatory protein in Alzheimer's disease
MA Smith, K Wehr, PLR Harris, SL Siedlak, JR Connor… - Brain research, 1998 - Elsevier
A role for altered iron metabolism in the pathogenesis of Alzheimer's disease has been
suggested by several reports associating the cardinal neuropathologic lesions with markers …
suggested by several reports associating the cardinal neuropathologic lesions with markers …
[HTML][HTML] The physiological functions of iron regulatory proteins in iron homeostasis-an update
DL Zhang, MC Ghosh, TA Rouault - Frontiers in pharmacology, 2014 - frontiersin.org
Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism
by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target …
by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target …
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice
MC Ghosh, WH Tong, D Zhang… - Proceedings of the …, 2008 - National Acad Sciences
In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also
known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2) …
known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2) …
Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis
S Bandyopadhyay, JT Rogers - Biochemical pharmacology, 2014 - Elsevier
The neurotoxicity of amyloid beta (Aβ), a major cleavage product of the amyloid precursor
protein (APP), is enhanced by iron, as found in the amyloid plaques of Alzheimer's disease …
protein (APP), is enhanced by iron, as found in the amyloid plaques of Alzheimer's disease …