Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

Nuclear receptors belong to a superfamily of ligand-inducible transcription factors that, in
addition to directly regulating their cognate gene programs, can also mutually interfere with …

Nuclear receptors are classically defined as ligand-activated transcription factors that
regulate key functions in reproduction, development, and physiology. Humans have 48 …

Nuclear receptors (NRs) regulate and coordinate multiple processes by integrating internal
and external signals, thereby maintaining homeostasis in front of nutritional, behavioral and …

Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other
receptor systems, in the appreciation that ligands may exert very diverse pharmacology …

The final installment of this series covers another class of transcriptional regulators termed
“orphan receptors” belonging to this large superfamily. The orphan nuclear receptors are …

Nuclear receptors are ligand‐inducible transcription factors that specifically regulate the
expression of target genes involved in metabolism, development, and reproduction. Their …

Nuclear receptors are members of a large family of ligand-inducible transcription factors that
regulate gene programs underlying a plethora of (patho) physiological phenomena. The …

Nuclear hormone receptors comprise a superfamily of ligand-activated transcription factors
that control development, differentiation, and homeostasis. Over the last 15years a growing …