This study investigated heroin and its metabolites in vivo in the rat by using a high-
performance liquid chromatography-tandem mass spectrometry (GC-MS) method. After …

Heroin is de-acetylated in the body to morphine in two steps. The intermediate 6-
acetylmorphine (6-AM) is formed rapidly and is considered important for the …

A new analytical technique has been developed for the simultaneous determination of
heroin, 6-monoacetylmorphine, morphine, morphine-6-and 3-glucuronides, and codeine in …

The metabolism of heroin was investigated in mice using a method which simultaneously
measured heroin and two of its biotransformation products, 6-monacetylmorphine (MAM) …

A high-performance liquid chromatography-tandem mass spectrometry (LC-MS-MS) method
has been developed for the quantitative analysis of heroin and its major metabolites 6 …

Heroin and its metabolites, 6‐monoacetylmorphine, morphine, and normorphine, were
determined in human urine with a GLC procedure. Heroin was extracted with chloroform at …

The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The
calibration curve for morphine in hair showed linear over 0.5–100 ng/mg hair. Though the …

In a previous study (Way et al., 1960), we reported that heroin is rapidly hydrolyzed in the
body to two products-namely, 6-monoacetylmorphine (MAM) and morphine (figure 1). The …

Although many deaths occur annually from heroin intoxication, the presence of heroin has
not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid …

After intake, heroin is metabolized almost instantaneously to 6-monoacetylmorphine (MAM),
which is then converted into morphine. The parent substance cannot, therefore, be spotted …