Right ventricular preload and afterload challenge induces contractile dysfunction and arrhythmia in isolated hearts of dystrophin‐deficient male mice
A Behrmann, J Cayton, MR Hayden… - Physiological …, 2024 - Wiley Online Library
Duchenne muscular dystrophy (DMD) is an X‐linked recessive myopathy due to mutations
in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and …
in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and …
Early right ventricular fibrosis and reduction in biventricular cardiac reserve in the dystrophin-deficient mdx heart
TA Meyers, DW Townsend - American Journal of …, 2015 - journals.physiology.org
Duchenne muscular dystrophy (DMD) is a progressive disease of striated muscle
deterioration. Respiratory and cardiac muscle dysfunction are particularly clinically relevant …
deterioration. Respiratory and cardiac muscle dysfunction are particularly clinically relevant …
Diaphragm rescue alone prevents heart dysfunction in dystrophic mice
A Crisp, HF Yin, A Goyenvalle, C Betts… - Human molecular …, 2011 - academic.oup.com
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most
cases, by the complete absence of the 427 kDa cytoskeletal protein, dystrophin. There is no …
cases, by the complete absence of the 427 kDa cytoskeletal protein, dystrophin. There is no …
Cardiac dysfunction and pathology in the dystrophin and utrophin-deficient mouse during development of dilated cardiomyopathy
JL Chun, R O'Brien, SE Berry - Neuromuscular Disorders, 2012 - Elsevier
Cardiac involvement in Duchenne muscular dystrophy is asymptomatic until function is
severely affected. Little is known about its evolution, and few animal models are available to …
severely affected. Little is known about its evolution, and few animal models are available to …
[HTML][HTML] Implications for cardiac function following rescue of the dystrophic diaphragm in a mouse model of Duchenne muscular dystrophy
CA Betts, AF Saleh, CA Carr, S Muses, KE Wells… - Scientific reports, 2015 - nature.com
Duchenne muscular dystrophy (DMD) is caused by absence of the integral structural protein,
dystrophin, which renders muscle fibres susceptible to injury and degeneration. This …
dystrophin, which renders muscle fibres susceptible to injury and degeneration. This …
Timeline of cardiac dystrophy in 3–18‐month‐old MDX mice
C Van Erp, D Loch, N Laws, A Trebbin… - Muscle & nerve, 2010 - Wiley Online Library
The dystrophin‐deficient (mdx) mouse remains the most commonly used model for
Duchenne muscular dystrophy (DMD). Mdx mice show a predominantly covert …
Duchenne muscular dystrophy (DMD). Mdx mice show a predominantly covert …
Voluntary exercise induces structural remodeling in the hearts of dystrophin‐deficient mice
JM Costas, DJ Nye, JB Henley, JH Plochocki - Muscle & nerve, 2010 - Wiley Online Library
In this exploratory study, we test the hypothesis that voluntary exercise affects the
progression of dystrophic changes in the left ventricle of the heart. Wild‐type …
progression of dystrophic changes in the left ventricle of the heart. Wild‐type …
Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy
Y Li, S Zhang, X Zhang, J Li, X Ai, L Zhang… - Cardiovascular …, 2014 - academic.oup.com
Aims To determine whether altered beta-adrenergic responses contribute to early cardiac
dysfunction in mdx (X-linked muscular dystrophy) mice, an animal model for human …
dysfunction in mdx (X-linked muscular dystrophy) mice, an animal model for human …
Cardiovascular phenotype of the Dmdmdx rat – a suitable animal model for Duchenne muscular dystrophy
PL Szabó, J Ebner, X Koenig… - Disease Models & …, 2021 - journals.biologists.com
Besides skeletal muscle abnormalities, Duchenne muscular dystrophy (DMD) patients
present with dilated cardiomyopathy development, which considerably contributes to …
present with dilated cardiomyopathy development, which considerably contributes to …
[HTML][HTML] Ex Vivo Stretch Reveals Altered Mechanical Properties of Isolated Dystrophin-Deficient Hearts
MS Barnabei, JM Metzger - PLoS One, 2012 - journals.plos.org
Duchenne muscular dystrophy (DMD) is a progressive and fatal disease of muscle wasting
caused by loss of the cytoskeletal protein dystrophin. In the heart, DMD results in …
caused by loss of the cytoskeletal protein dystrophin. In the heart, DMD results in …