Cancer stem cells (CSCs), enabled to self-renew, differentiate, and initiate the bulk tumor,
are recognized as the culprit of treatment resistance, metastasis, and recurrence …

Doxorubicin (DOX) has been extensively used to treat a wide range of cancers in free and
nanotized form. Nanotization of DOX has alleviated its toxicity and efflux-mediated …

Excessive oxidative stress in cancer cells can induce cancer cell death. Anticancer activity
and drug resistance of chemotherapy are closely related to the redox state of tumor cells …

Background Multidrug resistance (MDR) generally leads to breast cancer treatment failure.
The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) …

Chemotherapy is a major therapeutic option for cancer patients. However, its effectiveness is
challenged by chemodrugs' intrinsic pathological interactions with residual cancer cells …

Herein, we first report pH-responsive SeNPs stabilized with modified folic acid-N-trimethyl
chitosan (TMC-FA) as nanocarriers for delivery of doxorubicin (DOX) to overcome drug …

A key challenge of chemotherapy in clinical treatments is multidrug resistance (MDR), which
mainly arises from drug efflux-induced tumor cell survival. Thus, it is necessary to provide …

With the extensive application of doxorubicin (DOX), DOX resistance has become one of the
main obstacles to the effective treatment of breast cancer. In this paper, DOX and resveratrol …

Reactive oxygen species (ROS) as well-known endogenous stimuli has been widely used to
activate drug delivery systems (DDSs) for tumor-specific therapy. Unfortunately, endogenous …

Dendrimers are synthetic nanocarriers that comprise a highly branched spherical polymer
as new, efficient tools for drug delivery. However, the fate of nanocarriers after being …