Publisher Summary This chapter attempts to identify the principles and issues elucidated in
animal models that may provide insights for the development of effective approaches to …

When we last reviewed in detail the nature of tumor antigens on virus-induced, chemically-
and UV light-induced, mutagenized and" spontaneous" tumors in 1992 (Melief 1992), all …

Adoptive immunotherapy: Engineering T cell responses as biologic weapons for tumor mass
destruction: Cancer Cell Skip to Main Content Advertisement Cancer Cell This journal offers …

The transfusion of T cells, also called adoptive T cell therapy, is an effective treatment for
viral infections and has induced regression of cancer in early-stage clinical trials. However …

T-cells play an important role in in vivo tumor rejection in many animal tumor models and in
human melanoma. Many human tumor antigens recognized by autologous T-cells have now …

Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive
strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have …

Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte
defined tumor antigens, several antigens have been identified and characterized for …

Adoptive T‐cell therapy involves the isolation, expansion, and reinfusion of T lymphocytes
with a defined specificity and function as a means to eradicate cancer. Our research has …

To study T cell responses to tumors in an autochthonous model, we expressed a CD8 T cell
epitope SIYRYYGL (SIY) in the prostate of transgenic adenocarcinoma (TRAMP) mice …

Studies of T cell responses to tumors have focused on the draining lymph node (LN) as the
site of activation. We examined the tumor mass as a potential site of activation after adoptive …