[HTML][HTML] Glioblastoma targeted therapy: updated approaches from recent biological insights

M Touat, A Idbaih, M Sanson, KL Ligon - Annals of Oncology, 2017 - Elsevier
Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …

Emerging therapies for glioblastoma: current state and future directions

L Rong, N Li, Z Zhang - Journal of Experimental & Clinical Cancer …, 2022 - Springer
Glioblastoma (GBM) is the most common high-grade primary malignant brain tumor with an
extremely poor prognosis. Given the poor survival with currently approved treatments for …

New approaches to glioblastoma

M Khasraw, Y Fujita, C Lee-Chang… - Annual review of …, 2022 - annualreviews.org
Faced with unique immunobiology and marked heterogeneity, treatment strategies for
glioblastoma require therapeutic approaches that diverge from conventional oncological …

Glioma targeted therapy: insight into future of molecular approaches

K Yang, Z Wu, H Zhang, N Zhang, W Wu, Z Wang… - Molecular Cancer, 2022 - Springer
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?

S Tanaka, DN Louis, WT Curry, TT Batchelor… - Nature reviews Clinical …, 2013 - nature.com
Glioblastomas are heterogeneous neoplasms that are driven by complex signalling
pathways, and are among the most aggressive and challenging cancers to treat. Despite …

[HTML][HTML] Development of targeted therapies in treatment of glioblastoma

YY Xu, P Gao, Y Sun, YR Duan - Cancer biology & medicine, 2015 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is a type of tumor that is highly lethal despite maximal therapy.
Standard therapeutic approaches provide modest improvement in progression-free and …

From signalling pathways to targeted therapies: unravelling glioblastoma's secrets and harnessing two decades of progress

B Dewdney, MR Jenkins, SA Best, S Freytag… - … and Targeted Therapy, 2023 - nature.com
Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

Management of glioblastoma: State of the art and future directions

AC Tan, DM Ashley, GY López… - CA: a cancer journal …, 2020 - Wiley Online Library
Glioblastoma is the most common malignant primary brain tumor. Overall, the prognosis for
patients with this disease is poor, with a median survival of< 2 years. There is a slight …

The challenges associated with molecular targeted therapies for glioblastoma

TR Jue, KL McDonald - Journal of Neuro-Oncology, 2016 - Springer
Glioblastoma (GBM) is the most aggressive malignant brain tumor in adults. Improvements
in the treatment of GBM have remained static since the advent of the standard therapy which …

Current challenges and opportunities in treating glioblastoma

A Shergalis, A Bankhead, U Luesakul… - Pharmacological …, 2018 - ASPET
Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …