Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

S Chen, H Zhu, Y Luo - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Oral colon-targeted delivery systems (OCDSs) have attracted great attention in the delivery
of active compounds targeted to the colon for the treatment of colon and non-colon diseases …

Recent trends in design and evaluation of chitosan-based colon targeted drug delivery systems: Update 2020

M Kurakula, S Gorityala, K Moharir - Journal of Drug Delivery Science and …, 2021 - Elsevier
Colon-targeted drug delivery systems is an active area of research that is designed to
selectively release the drug in the colonic environment to enhance the oral delivery of active …

Chitosan: a potential polymer for colon-specific drug delivery system

A Gulbake, SK Jain - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: There is an enormous growth and awareness of the potential applications of
natural polymers for colon delivery of therapeutic bioactives. Chitosan (CH), a cationic …

Advances and applications of chitosan-based nanomaterials as oral delivery carriers: A review

X Lang, T Wang, M Sun, X Chen, Y Liu - International journal of biological …, 2020 - Elsevier
The oral drug administration was convenient and comfortable route for patients.
Nevertheless, the oral uptake efficiency of many therapeutic agents was limited by …

Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease

N Kulkarni, P Jain, A Shindikar, P Suryawanshi… - Carbohydrate …, 2022 - Elsevier
Chitosan is the polymer of choice for delivery of the active moieties to the colon due to its
cationic nature that enables strong mucosal attachment. Chitosan is explored for …

Potential applications of chitosan-based nanomaterials to surpass the gastrointestinal physiological obstacles and enhance the intestinal drug absorption

N Pathomthongtaweechai, C Muanprasat - Pharmaceutics, 2021 - mdpi.com
The small intestine provides the major site for the absorption of numerous orally
administered drugs. However, before reaching to the systemic circulation to exert beneficial …

Recent advances in colon drug delivery systems

R Arévalo-Pérez, C Maderuelo, JM Lanao - Journal of Controlled Release, 2020 - Elsevier
As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

Recent advancement in chitosan-based nanoparticles for improved oral bioavailability and bioactivity of phytochemicals: Challenges and perspectives

SS Imam, S Alshehri, MM Ghoneim, A Zafar… - Polymers, 2021 - mdpi.com
The excellent therapeutic potential of a variety of phytochemicals in different diseases has
been proven by extensive studies throughout history. However, most phytochemicals are …

Current advances in multifunctional nanocarriers based on marine polysaccharides for colon delivery of food polyphenols

S Tie, M Tan - Journal of Agricultural and Food Chemistry, 2022 - ACS Publications
Inflammatory bowel disease (IBD) has been considered as a chronic disease that is difficult
to cure and needs lifelong treatment. Marine polysaccharides with good biocompatibility and …

Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

MC Chen, FL Mi, ZX Liao, CW Hsiao, K Sonaje… - Advanced drug delivery …, 2013 - Elsevier
Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal
absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive …