Potential roles of selectins in periodontal diseases and associated systemic diseases: could they be targets for immunotherapy?

M Zhong, J Huang, Z Wu, KG Chan, L Wang… - International Journal of …, 2022 - mdpi.com
Periodontal diseases are predisposing factors to the development of many systemic
disorders, which is often initiated via leukocyte infiltration and vascular inflammation. These …

Immunological insights of selectins in human disease mechanism

C Selvaraj, R Abhirami, R Vijayakumar, FA Alfaiz… - Advances in protein …, 2022 - Elsevier
Selectin enzymes are glycoproteins and are an important adhesion molecule in the
mammalian immune system, especially in the inflammatory response and the healing …

Selectin-mediated leukocyte trafficking during the development of autoimmune disease

S Angiari - Autoimmunity reviews, 2015 - Elsevier
Tissue inflammation is a finely regulated process that controls wound healing and allows the
clearance of damaged cells, pathogens and irritants. However, excessive or uncontrolled …

Selectins—an emerging target for drug delivery

C Ehrhardt, C Kneuer, U Bakowsky - Advanced drug delivery reviews, 2004 - Elsevier
Selectins are multifunctional adhesion molecules that mediate the initial interactions
between circulating leukocytes and cells of the endothelium. First identified over a decade …

Selectins: critical mediators of leukocyte recruitment

KD Patel, SL Cuvelier, S Wiehler - Seminars in immunology, 2002 - Elsevier
Selectins are multi-functional adhesion molecules that mediate the initial interactions
between circulating leukocytes and the endothelium. First identified over a decade ago …

Modulation of P-selection and platelet aggregation in chronic periodontitis: a clinical study

R Perumal, M Rajendran… - Journal of Indian …, 2014 - journals.lww.com
Background: The primary etiologic factor of periodontitis is the subgingival infection with a
group of Gram negative pathogens. Transient bacteremia in periodontitis patients underlie …

Periodontopathogens induce soluble P-selectin release by endothelial cells and platelets

A Assinger, E Buchberger, M Laky, A Esfandeyari… - Thrombosis research, 2011 - Elsevier
INTRODUCTION: Soluble P-selectin plays a pivotal role in inflammation and the
development of thrombotic and cardiovascular disease. Accordingly, elevated levels of …

Inhibitors of selectin functions in the treatment of inflammatory skin disorders

MP Schön - Therapeutics and Clinical Risk Management, 2005 - Taylor & Francis
Selectins mediate tethering and rolling of leukocytes to the vascular endothelium, the first
adhesive step in the recruitment of immune cells to inflamed tissues. Thus, selectins play a …

Influence of sE‐selectin and L‐selectin on the regulation of cell migration during chronic periodontitis

W Krugluger, A Nell, P Solar, M Matejka… - Journal of …, 1995 - Wiley Online Library
Soluble endothelial leukocyte adhesion molecule‐1 (sE‐selectin) levels in peripheral blood
(PB) and gingival capillary blood (GCB) of both healthy donors (HD) and patients with adult …

Selectins and their ligands as potential immunotherapeutic targets in neurological diseases

S Angiari, G Constantin - Immunotherapy, 2013 - Taylor & Francis
Selectins are a family of adhesion receptors that bind to highly glycosylated molecules
expressed on the surface of leukocytes and endothelial cells. The interactions between …