Inhibition of toll-like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics
W Gao, Y Xiong, Q Li, H Yang - Frontiers in physiology, 2017 - frontiersin.org
The recognition of invading pathogens and endogenous molecules from damaged tissues
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …
Toll-like receptors: promising therapeutic targets for inflammatory diseases
The health of living organisms is constantly challenged by bacterial and viral threats. The
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
recognition of pathogenic microorganisms by diverse receptors triggers a variety of host …
Toll-like receptors activation, signaling, and targeting: an overview
SR El-Zayat, H Sibaii, FA Mannaa - Bulletin of the National Research …, 2019 - Springer
Abstract Background Toll-like receptors (TLRs) are an important family of receptors that
constitute the first line of defense system against microbes. They can recognize both …
constitute the first line of defense system against microbes. They can recognize both …
Is targeting Toll‐like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine‐driven inflammation?
E Andreakos, B Foxwell, M Feldmann - Immunological reviews, 2004 - Wiley Online Library
Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …
[HTML][HTML] Toll-like receptors in the pathogenesis of autoimmune diseases
AM Hosseini, J Majidi, B Baradaran… - Advanced …, 2015 - ncbi.nlm.nih.gov
Abstract Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which
play a key role in both innate and adaptive immune responses. Beside of recognizing …
play a key role in both innate and adaptive immune responses. Beside of recognizing …
Targeting Toll-like receptors with small molecule agents
Toll-like receptors (TLRs) are type I transmembrane proteins that are key regulators of both
innate and adaptive immune responses. To protect the host from viral and bacterial threats …
innate and adaptive immune responses. To protect the host from viral and bacterial threats …
Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists
S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …
Negative regulatory approaches to the attenuation of Toll-like receptor signaling
Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is
responsible for eradicating invading microorganisms through the induction of inflammatory …
responsible for eradicating invading microorganisms through the induction of inflammatory …
Recent progress in the development of Toll-like receptor (TLR) antagonists
ABSTRACT Introduction: Pattern recognition receptors (PRRs) of the innate immune system
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
mediate and control the activation and progression of adaptive immunity. Toll-like receptors …
The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases
Toll-like receptors (TLRs) form a family of pattern recognition receptors with at least 11
members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived …
members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived …