Precision medicine is an approach that takes into account the influence of individuals'
genes, environment, and lifestyle exposures to tailor interventions. Here, we describe the …

Although cancer research is progressing at an exponential rate, translating this knowledge
to develop better cancer drugs and more effectively match drugs to patients is lagging …

Current efforts in precision oncology largely focus on the benefit of genomics-guided
therapy. Yet, advances in sequencing techniques provide an unprecedented view of the …

Recent rapid biotechnological breakthroughs have led to the identification of complex and
unique molecular features that drive malignancies. Precision medicine has exploited next …

Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived …

Abstract The AACR Project GENIE is an international data-sharing consortium focused on
generating an evidence base for precision cancer medicine by integrating clinical-grade …

Current estimates from the American Cancer Society and from the International Union
Against Cancer indicate that 12 million cases of cancer were diagnosed last year, with 7 …

Over the last few decades, study of cancer in mouse models has gained popularity.
Sophisticated genetic manipulation technologies and commercialization of these murine …

Background Personalized therapy provides the best outcome of cancer care and its
implementation in the clinic has been greatly facilitated by recent convergence of enormous …

Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer
biology and develop novel precision medicine therapeutics. However, utilizing TOs for …