Despite the availability of various therapeutic classes of antihypertensive drugs,
hypertension remains poorly controlled, in part because of poor adherence. Hence, there is …

Systemic hypertension is the leading cause of death and disability worldwide. The
management of hypertension is challenging in the high-risk patient population with high salt …

Background: Despite existing therapy, successful control of hypertension in the United
States is estimated at less than 50%. In blacks, hypertension occurs earlier, is more severe …

An unfortunate subset of hypertensive patients develops resistant hypertension in which
optimal doses of three or more first-line antihypertensive drugs fail to sufficiently control …

The pathophysiology of heart failure (HF) and hypertension are thought to involve brain
renin-angiotensin system (RAS) hyperactivity. Angiotensin III, a key effector peptide in the …

Angiotensin (Ang)-converting enzyme 2 (ACE2) cleaves Ang II to form Ang-(1-7). Here we
examined whether soluble human recombinant ACE2 (rACE2) can efficiently lower Ang II …

Global incidence and prevalence of hypertension continues to increase and remains a
significant challenge. The ever-increasing number of cases are due to comorbid conditions …

Rationale: Angiotensin converting enzyme type 2 (ACE2) is a new member of the brain renin-
angiotensin system, that might be activated by an overactive renin-angiotensin system …

Among the main bioactive peptides of the brain renin–angiotensin system, angiotensin
(Ang) II and AngIII exhibit the same affinity for the type 1 and type 2 Ang receptors. Both …

The brain renin–angiotensin system (RAS) plays an important role in the regulation of
autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II …